نتایج جستجو برای: tyrosine kinase inhibitor

تعداد نتایج: 426607  

Journal: :The Biochemical journal 2006
Pietro Minuz Laura Fumagalli Stefania Gaino Rosa M Tommasoli Maurizio Degan Chiara Cavallini Anna Lecchi Marco Cattaneo Clara Lechi Santonastaso Giorgio Berton

Signals ensuing from trimeric G-protein-coupled receptors synergize to induce platelet activation. At low doses, the thromboxane A2 analogue U46619 does not activate integrin alphaIIbbeta3 or trigger platelet aggregation, but it induces shape changes. In the present study, we addressed whether low doses of U46619 trigger tyrosine phosphorylation independently of integrin alphaIIbbeta3 activatio...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2000
B Tolloczko F C Tao M E Zacour J G Martin

Contractile agonists may stimulate mitogenic responses in airway smooth muscle by mechanisms that involve tyrosine kinases. The role of contractile agonist-evoked activation of tyrosine kinases in contractile signaling is not clear. We addressed this issue using cultured rat airway smooth muscle cells. In these cells, serotonin (5-HT, 1 microM) caused contraction (quantitated by a decrease in c...

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