Erythema nodosum (EN) is a delayed-type hypersensitivity reaction that most often presents as erythematous, tender nodules on the shins. Common triggers for EN include infection, drugs, pregnancy, malignancy, and inflammatory conditions, such sarcoidosis or gastrointestinal diseases; however, many cases are idiopathic. We present clinical case of 12 y.o girl with associated EBV.