To investigate the channels and neurotransmitters in the ventrolateral medulla (VLM) oblongata that are responsible for the maintenance of sympathetic tone and cardio-respiratory reflex regulation. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM), calcium channel blockers, agonists and antagonists were made throughout the VLM in anaesthetized rats. Arterial blood pressure, sym...

Calcium-induced calcium release (CICR) has been observed in cardiac myocytes as elementary calcium release events (calcium sparks) associated with the opening of L-type Ca 2 1 channels. In heart cells, a tight coupling between the gating of single L-type Ca 2 1 channels and ryanodine receptors (RYRs) underlies calcium release. Here we demonstrate that L-type Ca 2 1 channels activate RYRs to pro...

AIMS/INTRODUCTION Recent studies have shown the association between blood pressure variability and cardiovascular events. The present study was designed to investigate the relationship between antihypertensive drug class and home blood pressure variability in patients with type 2 diabetes. MATERIALS AND METHODS We compared home blood pressure variability among patients treated with calcium ch...

The effects of auxiliary calcium channel subunits on the expression and functional properties of high-voltage activated (HVA) calcium channels have been studied extensively in the Xenopus oocyte expression system, but are less completely characterized in a mammalian cellular environment. Here, we provide the first systematic analysis of the effects of calcium channel beta and alpha(2)-delta sub...

Channelopathies are often linked to defective protein folding and trafficking. Among them, the calcium channelopathy episodic ataxia type-2 (EA2) is an autosomal dominant disorder related to mutations in the pore-forming Ca(v)2.1 subunit of P/Q-type calcium channels. Although EA2 is linked to loss of Ca(v)2.1 channel activity, the molecular mechanism underlying dominant inheritance remains uncl...

Besides its effect on high blood pressure, T-type calcium channel blocker is renoprotective in experimental models of renal fibrosis. However, the exact mechanism of T-type calcium channel blocker on tubulointerstitial fibrosis is unclear. We investigated whether the renoprotective effect of T-type calcium channel blocker is associated with modulation of the signaling of oxidative stress-induce...

To report the association between SARS-CoV-2 and Anti- N -Type Calcium Channel antibody positive, EEG MRI-negative encephalitis with a treatment response to plasmapheresis. Postinfectious neuropsychiatric complications are common but pathogenesis remains poorly understood. We case of autoimmune subacute onset after SARS-CoV -2infection positive cerebrospinal fluid serology for Anti-N-Type-Calci...

After brief periods of heightened stimulation, calcium entry through L-type calcium channels leads to activation of the transcription factor cAMP response element-binding protein (CREB) and CRE-dependent transcription. Many of the details surrounding the mechanism by which L-type calcium channels are privileged in signaling to CREB, to the exclusion of other calcium entry pathways, has remained...

Cardiovascular complications are common in patients with Diabetes mellitus (DM). In addition to changes in cardiac muscle inotropy, electrical abnormalities are also commonly observed in these patients. We have previously shown that spontaneous cellular electrical activity is altered in atrioventricular nodal (AVN) myocytes, isolated from the streptozotocin (STZ) rat model of type-1 DM. In this...

Taylor, James T., Luping Huang, Brian M. Keyser, Hean Zhuang, Craig W. Clarkson, and Ming Li. Role of high-voltage-activated calcium channels in glucose-regulated -cell calcium homeostasis and insulin release. Am J Physiol Endocrinol Metab 289: E900–E908, 2005. First published June 14, 2005; doi:10.1152/ajpendo.00101.2005.—Highvoltage-activated (HVA) calcium channels are known to be the primary...