نتایج جستجو برای: type 1 diabetes t1d
تعداد نتایج: 3777833 فیلتر نتایج به سال:
The health-promoting effects of various constituents of the olive tree (Olea europaea) are mainly associated with hypoglycaemic and insulin-sensitising activities and have been widely demonstrated in the metabolic syndrome and type 2 diabetes. However, their biological activity in autoimmune type 1 diabetes (T1D) is poorly characterised. Therefore, the influence of O. europaea-derived component...
We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a <1 Mb region on mouse chromosome 3. In this study, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of nove...
OBJECTIVE Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order ...
Incidence of Type 1 Diabetes in Finland The incidence of type 1 diabetes (T1D), one of themost prevalent chronicdisease inchildren,has increasedworldwide.1The highest recorded incidence in children younger than 15 years was 64.2 per 100000person-years inFinland in 2005.2Weexamined the incidence rates between 2006 and 2011 in Finnish children younger than 15 years as well as the 32-year trend (1...
The development of type 1 diabetes (T1D) has been linked to environmental factors and dietary components. Increasing evidence indicates that the integrity of the gut mucosa plays a role in the development of autoimmune diseases, and evidence from both preclinical and clinical studies demonstrates that increased leakiness of the intestinal epithelium precedes the development of type 1 diabetes. ...
Background Obesity is associated with risk of clinical and metabolic complications such as dyslipidemia, hypertension and diabetes. Previous studies have demonstrated that visceral obesity is related to type 2 diabetes, cardiovascular disease and insulin resistance (IR). This study aims to evaluate the relationship between different markers of body adiposity and IR in adults with type 1 diabete...
BACKGROUND Recently, natural mutation of Tyrosine kinase 2 (Tyk2) gene has been shown to determine susceptibility to murine virus-induced diabetes. In addition, a previous human genome-wide study suggested the type 1 diabetes (T1D) susceptibility region to be 19p13, where the human TYK2 gene is located (19p13.2). METHODS Polymorphisms of TYK2 gene at the promoter region and exons were studied...
Diabetes mellitus type 1 (T1D) is a complex disease resulting from the interplay of genetic, epigenetic, and environmental factors. Recent progress in understanding the genetic basis of T1D has resulted in an increased recognition of childhood diabetes heterogeneity. After the initial success of family-based linkage analyses, which uncovered the strong linkage and association between HLA gene v...
OBJECTIVEdImpaired awareness of hypoglycemia (IAH) and defective counterregulation significantly increase severe hypoglycemia risk in type 1 diabetes (T1D). We evaluated restoration of IAH/defective counterregulation by a treatment strategy targeted at hypoglycemia avoidance in adults with T1D with IAH (Gold score $4) participating in the U.K.-based multicenter HypoCOMPaSS randomized controlled...
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