PURPOSE To correlate intra voxel incoherent motion (IVIM) diffusion parameters of liver parenchyma and hepatocellular carcinoma (HCC) with degree of liver/tumor enhancement and necrosis; and to assess the diagnostic performance of diffusion parameters vs. enhancement ratios (ER) for prediction of complete tumor necrosis. PATIENTS AND METHODS In this IRB approved HIPAA compliant study, we incl...

Bacterial endotoxin (lipopolysaccharide) depresses cardiovascular function; however, the mediators and signaling pathways that are responsible for the negative inotropic effects of lipopolysaccharide are not fully known. We used RNA interference to determine the relative role of tumor necrosis factor with respect to mediating the negative inotropic effects of lipopolysaccharide in isolated card...

Macrophages and their immature undifferentiated predecessors, monocytes, are part of the innate immune system with primary function in defense against infection, malignancy and in immunity. Of the various protein mediators produced by monocytes/macrophages are proinflammatory cytokines such as tumour necrosis factorα (TNF-α), interleukin-1 (IL-1β) and IL-6. The regulated release of these cytoki...

Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasia of gastrointestinal system. Radical surgery with negative margin is important step for treatment GIST. The primary aim this study was to evaluate risk factors recurrence in patients who underwent diagnosis Secondary reveal that affect survival. Materials and Methods: data 28 GIST our clinic between January 201...

OBJECTIVES To determine the effect of severe sepsis on monocyte tumor necrosis factor-α-converting enzyme baseline and inducible activity profiles. DESIGN Observational clinical study. SETTING Mixed surgical/medical teaching hospital ICU. PATIENTS Sixteen patients with severe sepsis, 15 healthy volunteers, and eight critically ill patients with noninfectious systemic inflammatory response...