نتایج جستجو برای: tumor inhibition
تعداد نتایج: 715754 فیلتر نتایج به سال:
Angiogenesis is required for the progression of tumors from a benign to a malignant phenotype and for metastasis. Malignant tumor cells secrete factors such as vascular endothelial growth factor (VEGF), which bind to their cognate receptors on endothelial cells to induce angiogenesis. Here it is shown that several tumor types express VEGF receptors (VEGFRs) and that inhibition of VEGF (VEGF ant...
Abstract Immunotherapy has revolutionized cancer treatment but yet to be translated into brain tumors. Studies in melanoma and sarcoma, amongst other models, have revealed the accumulation of germinal-center-like B cells as a key survival predictor post-PD1 blockade. We seek leverage cell immunity enhance immunotherapy effectiveness glioblastoma (GBM). In human GBM murine glioma we found that t...
Biological therapy is opening up a new age for the treatment of cancer. The bacteria -cancer interaction was firstly observed by Busch and Fehleisen (1). To reducing potential pathogenicity using active bacterial, bacterial products like proteins, enzymes, immune-toxins, that straightaway target malignancy cells regress volume tumor through expansion inhibition, induction apoptosis (2). This st...
Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target for developing cancer therapeutics. Using preclinical models, we characterized the anti-tumor activity of a small molecule inhibitor of TGFβ receptor I (TGFβRI), galunisertib (LY2157299 monohydrate). Galunisertib demonstrated potent and selecti...
In this review, in the search for the development of new anticancer drugs, the effects of compounds isolated from various medicinal plants on tumor growth and metastasis, using mice bearing a highly metastatic drug-resistant mouse tumor, were studied. The antitumor and antimetastatic actions of stilbene derivatives isolated from Polygonum and Cassia species were examined. Among the stilbene der...
Tumor-derived prostaglandin E2 (PGE2) modifies cytokine balance and inhibits host immunity. We hypothesized that a high level of PGE2 production by lung tumor cells is dependent on tumor cyclooxygenase (COX)-2 expression. We found that PGE2 production by A549 non-small cell lung cancer (NSCLC) cells was elevated up to 50-fold in response to interleukin (IL)-1beta. Reversal of IL-1beta-induced P...
Activation of GLI1 which is the transcription factor through Hh signaling mediated has been shown to be a key step in initiation tumorigenic program leading BCC. We recently showed that was also regulated by insulin-like growth 2 mRNA binding protein 1 (IGF2BP1) at post-transcriptional level. IGF2BP1 direct target Wnt/β-catenin critical Wnt-dependent regulation GLI. observed upstream signal IGF...
Cellular senescence is a non-proliferative but viable state that can be induced by oncogene expression and anti-cancer therapeutics, such as BRAF inhibition, has long been considered beneficial tumor suppressive mechanism. However, senescent cells express well-characterized senescence-associated secretory phenotype (SASP), which may contribute to an immunosuppressive microenvironment increased ...
angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in the physiologic circumstances such as embryonic development, placenta formation, and wound healing. it is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. in general, angiogenesis process is a multi-factorial and highly structu...
Objective: Methanol extract of bran and unpolished grain of two traditional aromatic rice genotypes viz. Kalijira and Chinigura were assayed for their activity on the growth and initiation of crown-gall tumors on potato disks. Materials and Methods: Three Agrobacterium tumefaciens (A. tumefaciens) strain AtSl0105, AtTa0112, and AtAc0114 were used as the tumor forming agent. Collected rice was s...
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