Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. Here, we report a case of a 75-year-old man with metastatic malignant melanoma treated with a combination of nivolumab (an...

The role of the renal biopsy in lupus nephritis is to provide the diagnosis and to define the parameters of prognostic and therapeutic significance for an effective clinicopathological correlation. Various classification schemas initiated by World Health Organization in 1974 have been proposed until the most recent update by International Society of Nephrology/Renal Pathology Society in 2004. I...

INTRODUCTION Tubulointerstitial nephritis and uveitis syndrome (TINU Syndrome) is an uncommon clinical entity, and the majority of patients are adolescents and young women. The case reported refers to an elderly patient with ophthalmologic symptoms detected earlier than kidney manifestations, being probably the first case described in Brazil. CASE REPORT Female patient, 60 years-old, sought m...

Inflammatory bowel diseases (IBD) are two different types of chronic noninfectious gastrointestinal inflammatory diseases, namely Crohn’s disease and Ulcerative colitis. Renal involvement exists among the extraintestinal involvements IBD. IBD renal in form glomerulonephritis, tubulointerstitial nephritis, nephrolithiasis, amyloidosis. In this article, a 79-year-old male patient who presented wi...

BACKGROUND Systemic hypertension is a risk factor for progression of renal disease. However, it is not clear whether hypertension has an effect on healing or regression of immune-mediated glomerular damage. To evaluate this effect, we applied a model of glomerulonephritis in rats with two-kidney, one-clip hypertension and studied the effect of hypertension on the healing process of this nephrit...

INTRODUCTION Glomerulonephritis is the third most common cause of end-stage renal disease. Epidemiological data of kidney disease is population-based and has great geographic variability. The aim of this study was to assess the results of all kidney biopsies in a 5-year period in the Guilan province. MATERIALS AND METHODS In a retrospective study of 336 kidney biopsies recorded in the Departm...

BACKGROUND Tubulointerstitial nephritis and uveitis [TINU] syndrome is a rare disorder that may also be underdiagnosed. Patients with TINU syndrome typically present with an acute bilateral nongranulomatous anterior uveitis following symptoms of systemic illness. FINDINGS We report the case of a 15-year-old girl who presented with acute granulomatous iridocyclitis and was diagnosed with TINU ...

Latin America is a large and diverse region. Therefore it is no surprise that the development and implementation of pharmacoeconomic (PE) guidelines is proceeding at a different pace in different jurisdictions. The first three articles in this special issue of Value in Health focusng on Latin America outline the challenges in the development and mplementation of guidelines in three country clus...

Acute interstitial nephritis is a rare complication of tetracycline therapy and there have been two case reports associated with minocycline [1,2]. In both cases the patients presented within 2 weeks of commencing the antibiotic with an acute febrile illness and loin pain, and an acute interstitial nephritis was confirmed on renal biopsy. We report a case of chronic interstitial nephritis in a ...