Background: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). Bacille Calmette-Guerin (BCG) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult TB vaccine. The aim of this study was to develop a new tuberculosis DNA vaccine candidate encoding a recombinant HspX-PPE44-EsxV fusion antigen of M. tuberculosis. Methods: ...

Tuberculosis (TB) is a deadly disease caused by the Mycobacterium tuberculosis bacteria which affects lungs. has become public health problem in Indonesia and around world. prevention one of goals Sustainable Health Development (SDGs). In year 2020, 17.3% TB patients were 45-54 years old, 16.8% 25-34 16.7% 15-24 old. The treatment coverage (TC) cases 2020 was 41.7%, lower than three ago. medica...

BACKGROUND Mycobacterium tuberculosis lipid antigens take part in pathogenicity of the bacterium but the response of monocytes/macrophages to these antigens in tuberculosis is not well known. OBJECTIVE The aim of current investigation was to study the M. tuberculosis lipid antigens in tuberculosis pathogenesis. METHODS In the present study M. tuberculosis lipid antigens were extracted. Mono...

Recent state-wide surveillance of drug-resistant tuberculosis in the state of Gujarat has shown resistance to flouroquinolones (FQ) in 24 per cent cases (19% among new and 25% among previously treated TB cases)1. This increase of drug resistance correlates well with the very widespread use (the broad indications of this class of antimicrobials in lower-respiratory, gastrointestinal, genitourina...

One-third of the world's population is infected with tuberculosis, only 10% will develop active disease and the remaining 90% is considered to have latent TB (LTB). While active TB is contagious and can be lethal, the LTB can evolve to active TB. The diagnosis of TB can be challenging, especially in the early stages, due to the variability in presentation and nonspecific signs and symptoms. Cur...

Tuberculosis as a social human disease has been known since ancient times. Morbidity and mortality from multidrug-resistant TB (MDR-TB) extensively drug-resistant (XDR-TB) both in RS(Y) the Russian Federation remain high. In recent years, studies have conducted on effectiveness of chemotherapy using drug bedaquiline. State Budgetary Institution Republic Sakha (Yakutia) SPC “Phthisiology”, presc...

Introduction: Tuberculosis is a chronic, highly contagious disease caused by the Bacillus Mycobacterium tuberculosis and spreads from person to through air. affects lungs majorly but also other parts of body, such as brain, intestine, spine kidney. The main cause for patient’s non-adherence anti-tuberculosis therapy ADRs varying degrees severity hepatotoxicity etc. Aim: This study aimed provide...

introduction: development of effective immunodiagnostic methods for detection of mycobacterium tuberculosis infection is crucial. serodiagnostic methods, based on antibody response to specific antigens could provide promising approaches for rapid, economical and easy to perform diagnostic tests which are crucial for tuberculosis (tb) control. in this study, the level of igg antibody responses a...