نتایج جستجو برای: tsc and tcrfc compensators
تعداد نتایج: 16827505 فیلتر نتایج به سال:
Absmd-Often in controi system design. i t is only necessary to estimate a single (but prespecified) linear function of the system's state for the purpose of implementing a feedback control law. This can be achieved by a linear functional observer which may have order one less than the observability index of the plant. but generically cannot have smaller order. In this paper, we explore the conc...
c-MYC stimulates cell proliferation through the suppression of cyclin-dependent kinase (CDK) inhibitors including P15 (CDKN2B) and P21 (CDKN1A). It also activates E-box-mediated transcription of various target genes including telomerase reverse transcriptase (TERT) that is involved in cellular immortality and tumorigenesis. Transforming growth factor-beta 1 (TGF-β1)-stimulated clone 22 (TSC-22/...
On July 10, 2016, Alfred G. Knudson, Jr., MD, PhD, a leader in cancer research, died at the age of 93 years. We deeply mourn his loss. Knudson's two-hit hypothesis, published in 1971, has been fundamental for understanding tumor suppressor genes and familial tumor-predisposing syndromes. To understand the molecular mechanism of two-hit-initiated tumorigenesis, Knudson used an animal model of a ...
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease that varies greatly in its expression. The current study reports a novel case of TSC caused by a TSC2 mutation (TSC2c.1642_1643insA or TSC2p.K549fsX589), in which multiple cardiac rhabdomyomas were detected by fetal echocardiography in week 31 of pregnancy. The infant was delivered successfully; however, seizures began 16...
The mammalian/mechanistic target of rapamycin (mTOR) signaling pathway plays critical roles in skeletal development. The impact and underlying mechanisms of its dysregulation in bone homeostasis is poorly defined. The best known and characterized mTOR signaling dysregulation in human disease is called Tuberous Sclerosis Complex (TSC). TSC is an autosomal dominant neurocutaneous syndrome with a ...
We present a novel method for independently controlling multiple stress-engineered MEMS microrobots (MicroStressBots) through a single, global, control signal. Called Turning-rate Selective Control (TSC), this new technique employs designed variations in turning rates between individual microrobots to differentiate their motion. Despite all robots moving simultaneously and being identical excep...
The paper is concerned with defining and parametrising the families of all degenerate compensators (feedback, squaring down etc) in a variety of linear control problems. Such compensators indicate the boundaries of the control design, but they also provide the means for linearising the nonlinear nature of the Determinantal Assignment Problems, which provide the unifying description for all freq...
Purpose10-year retrospective study to assess burden of illness in individuals with tuberous sclerosis complex (TSC) identified from German healthcare data.MethodsPatients TSC were by International Classification Diseases code Q85.1. Patients epilepsy diagnosis or antiseizure medication (ASM) prescription after diagnosis.ResultsUsing data 2016 (final year), 100 patients (mean [range] age: 38 [1–...
BACKGROUND Tuberous sclerosis complex (TSC) is a rare, multisystem, genetic disorder with an estimated prevalence between 1/6800 and 1/15000. Although recent years have seen huge progress in understanding the pathophysiology and in the management of TSC, several questions remain unanswered. A disease registry could be an effective tool to gain more insights into TSC and thus help in the develop...
Gas production (GP) and starch degradation (STAD) from starchy feedstuffs were measured simultaneously by in-vitro incubation in buffered rumen fluid after 0, 4, 6, 8, 12, 16 and 24 h incubation to explore the possibility to estimate STAD via GP technique for starchy feedstuffs. The results showed the ranking in the initial degree of starch degradation and gas production. Potato starch and maiz...
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