BACKGROUND Crizotinib, an ATP-competitive receptor tyrosine kinase inhibitor of both anaplastic lymphoma kinase (ALK) and the hepatocyte growth factor receptor, commonly causes several adverse events (AEs). The clinical utility of measuring the plasma concentration of crizotinib in patients with non-small-cell lung cancer (NSCLC) has not been fully elucidated. The aim of this study was to evalu...

BACKGROUND The tear trough and the lid/cheek junction become more visible with age. These landmarks are adjacent, forming in some patients a continuous indentation or groove below the infraorbital rim. Numerous, often conflicting procedures have been described to improve the appearance of the region. The purpose of this study was to evaluate the anatomy underlying the tear trough and the lid/ch...

In the title compound, C(31)H(7)BF(12)N(6)O, mol-ecules are arranged into one-dimensional columns with an inter-molecular B⋯B distance of 5.3176 (8) Å. Bowl-shaped mol-ecules are arranged within the columns in a concave bowl-to-ligand arrangement separated by a ring centroid distance of 3.532 (2) Å between the benzene ring of the 4-methyl-phen-oxy ligand and one of the three five-membered rings...

BACKGROUND Vancomycin hydrochloride treatment failure for infections caused by susceptible methicillin-resistant Staphylococcus aureus (MRSA) strains with high minimum inhibitory concentration (MIC) has prompted recent guidelines to recommend a higher vancomycin target trough of 15 to 20 microg/mL. METHODS A prospective cohort study of adult patients infected with MRSA was performed to determ...

This article investigates new relations with things that are expansive and inclusive of the pluralities differences within our entanglements technologies. We do this by extending commitments to methodological approaches material speculation co-speculation led us engage in multi-year conversations between ourselves as design researchers, philosophers, a counterfactual artifact we designed, known...

A model of cooperation versus defection in a sequence of games is analysed under the assumptions that the rules of the game are randomly changed from one encounter to another, that the decisions are to be made each time anew, according to the (random) rules of the specific local game, and that the result of one such game affects the ability of a player to participate and thus, cooperate in the ...

In this paper a class of large supergames, i.e., infinitely repeated games played by many players are studied. The players located on the vertex set of planar rectangle lattice play several basic games with his neighbors. The basic game is two-person prisoners’ dilemma game with asymmetric payoffs. Under the conditions of the pre-specified updating rules and the transition probabilities, the re...

The role of lateral ocean physics in the upper ocean thermal balance of a coupled ocean-atmosphere GCM Abstract The sensitivity of the upper ocean thermal balance of an ocean-atmosphere coupled GCM to lateral ocean physics is assessed. Three 40-year simulations are performed using horizontal mixing, isopycnal mixing , and isopycnal mixing plus eddy induced advection. The thermal adjustment of t...

BACKGROUND Existing data are not consistently supportive of improved clinical outcome when vancomycin dosing regimens aimed at achieving target trough levels are used. A retrospective, post hoc, subgroup analysis of prospectively collected data from the Phase 3 ATTAIN trials of telavancin versus vancomycin for treatment of nosocomial pneumonia was conducted to further investigate the relationsh...