PURPOSE To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney. MATERIALS AND METHODS Eight non-green fluorescent protein (GFP) transgenic Sprague- Dawley rats were mated with GFP-positive transgenic male rats. Renal damage was induced on the right kidney at gestational day 11. ...

329 stated that "The model was soon found to be unreliable, perhaps due to failure to document a lack of brain blood flow during the ischemic period and to nonstandardized postischemic supportive care, aspects of peri-ischemic handling that were not appreciated at this time." In fact, the model itself was never unreliable, as the results in our first report showed.' Indeed, in developing the mo...

The introduction of the Heisenberg Uncertainty principle and Nuclear Cardiology occurred simultaneously in 1925-1927. Thirty years later the Anger gamma camera would allow for a more sophisticated radioactive isotope counting to determine the presence or absence of disease. When employed with technetium-99m isotopes, ischemic heart disease can be inferred by differences in visual appearance of ...

The purpose of this study was to evaluate the feasibility and diagnostic accuracy of same day rest-stress myocardial perfusion SPECT (MP SPECT) protocol by using technetium-99m (Tc-99m) furifosmin in conjunction with dobutamine stress test in subjects in whom coronary artery disease (CAD) had been proven or excluded at coronary angiography (CA). The study group consisted of 25 patients (8 femal...

The present study evaluated whether technetium-99m sestamibi (99mTc-MIBI) single photon emission computed tomography (SPECT) characteristics of intracranial meningioma are correlated with the histological malignancy, proliferative potential, and P-glycoprotein (Pgp) expression, encoded by the multidrug resistance gene-1 (MDR-1) messenger ribonucleic acid (mRNA). Twenty-one patients with intracr...

The method for subtracting the initial image from the localization image was evaluated for radioimmunoscintigraphy of tumors with technetium-99m (Tc-99m) labeled antibodies. Monoclonal antibodies were parental mouse and mouse-human chimeric antibodies to carcinoembryonic antigen (CEA), designated F11-39 and ChF11-39, respectively, both of which have been found to discriminate CEA in tumor tissu...

OBJECTIVE Technetium-99m sestamibi (MIBI) has been utilized to evaluate multi-drug resistance (MDR) phenomenon of malignant tumors and to predict chemotherapeutic effects on them. The current investigation examined the possibility of monitoring changes with respect to mRNA expression of multi-drug resistance associated protein (MRP) following antisense oligodeoxynucleotide (AS-ODN) treatment in...

UNLABELLED We describe the engineering of a novel single-chain fragment (scFv) metallothionein (MET) containing anti-carcinoembryonic antigen (CEA) antibody (referred to as MET-scFv) for use as a diagnostic imaging agent in colorectal cancer. METHODS Site-directed cloning of annealed oligonucleotides, containing both the MET and a c-myc tag sequence, into a pUC19-based expression vector enabl...

BACKGROUND Noscapine, an alkaloid from Papaver somniferum, widely used as an antitussive, is being clinically studied in the treatment of polycystic ovary syndrome (PCOS) and a few other cancers primarily because of its anti-angiogenesis properties. With the advent of diverse application of noscapine, we sought to determine whether the radiolabeling method can be useful in studying uptake and k...

s | 97 Specifically, we examined factors influencing female North Korean refugees’ quality of life. The sample was comprised 172 female North Korean refugees. Participants completed the checklist for Health Condition, the Posttraumatic Stress Disorder Checklist-civilian version (PLC-C; Weathers et al., 1993), the Multidimensional Scale of Perceived Social Support, Zimet et al., 1988), and the K...