The tight ion pair [EtZn(η(3)-C(6)H(6))][CHB(11)Cl(11)]·C(6)H(6) (1·C(6)H(6)) was obtained through β-hydrogen abstraction and concomitant ethene elimination from Et(2)Zn with the trityl salt [Ph(3)C][CHB(11)Cl(11)]. This ionlike species shows catalytic activity in hydrosilylation and intramolecular hydroamination reactions. The amine adduct {CH(2)CHCH(2)C(Ph(2))CH(2)NH(2)}(3)ZnCB(11)Cl(11) (3),...

1-Acetoxyethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3- [(Z)-1-propenyl]-3-cephem-4-carboxylate (BMY-28271) is an ester-type prodrug of cephalosporin for oral use. Methods suitable for large scale preparation were investigated. The yield was improved by esterification of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-trityloxyiminoacetamido]cep hem-4-carboxylic acid (11) followed by removal...

We report the dynamic nuclear polarization of (1)H spins in magic-angle-spinning spectra recorded at 5 T and 84 K via the solid effect using Mn(2+) and Gd(3+) complexes as polarizing agents. We show that the magnitude of the enhancements can be directly related to the effective line width of the central (m(S) = -1/2 → +1/2) EPR transition. Using a Gd(3+) complex with a narrow central transition...

Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationally restrained amide derivatives as inhibitors PfdUTPase, including both acyclic and cyclic examples. Activity was dependent on the orientation and location of the amide constraining group. In the ca...

conclusions the results of this study supported the potential protective effects of zncl2 on rat kidney tissues against cdcl2 toxicity. results in contrast to the animals that received zncl2, cdcl2 induced a dose-dependent elevation in bun, creatinine, and mda in those without zncl2 pretreatment. zinc chloride had significantly decreased all biochemical parameters and protected kidney cells aga...