BACKGROUND Lymphangioleiomyomatosis (LAM) is a rare disease affecting young women caused by abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs and extrapulmonary sites (extrapulmonary LAM). The objective of this case series is to demonstrate marked regression in 2 cases of retroperitoneal LAM after treatment with everolimus, an mTOR inhibitor. METHODS We enrolled 2 ca...

Lymphangioleiomyomatosis (LAM) is a progressive disease caused by accumulation of metastatic (LAM) cells in the lungs, lymphatics, and the tumor angiomyolipoma (AML). LAM cells have biallelic loss of either tuberous sclerosis complex gene (but predominantly TSC-2) and resultant dysregulation of the mammalian target of rapamycin (mTOR) pathway. Chemokines are associated with neoplastic cell grow...

BACKGROUND Understanding the true prevalence of lymphangioleiomyomatosis (LAM) is important in estimating disease burden and targeting specific interventions. As with all rare diseases, obtaining reliable epidemiological data is difficult and requires innovative approaches. AIM To determine the prevalence and incidence of LAM using data from patient organizations in seven countries, and to us...

Petunia hybrida Vilm. ‘PxPc6’ 2.85 Marie and Brown (1993) Pisum sativum L. ‘Ctirad’ 9.08 Doležel et al. (1998) Pisum sativum L. ‘Express Long’ 8.37 Marie and Brown (1993) Pisum sativum L. ‘Minerva Maple’ 9.72 Bennett and Smith (1991) Raphanus sativus L. ‘Saxa’ 1.10 Doležel et al. (1992) Salvia brachyodon Vandas 0.95 Siljak-Yakovlev et al. (2010) Secale cereale L. ‘Daňkovské’ 16.18 Doležel et al...

Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance indicates that estrogen plays a critical role in LAM pathogenesis, and we have proposed that estrogen promotes LAM cell metastasis by inhibition of ...

Certification challenges and higher than anticipated development costs for the Local Area Augmentation System (LAAS) have motivated the investigation of alternative approaches for achieving Category I precision approach and landing service. One proposed alternative is the Local Airport Monitor (LAM). This concept would rebroadcast Wide Area Augmentation System (WAAS) differential corrections in...

The crop yield and quality of seven annual forages (four grasses three legumes) in sole mixtures (ratio 50:50) for oat (Avena sativa L.), Italian ryegrass (Lolium multiflorum Lam.), triticale (x Triticosecale Wittmack), barley (Hordeum vulgare pea (Pisum sativum berseem (Trifolium alexandrinum L.) common vetch (Vicia were evaluated a two-year field experiment adopting two harvesting times, gree...

AIMS/BACKGROUND This study was to investigated the synergistic effect of polyherbal formulations (PHF) of Allium sativum L., Eugenia jambolana Lam., Momordica charantia L., Ocimum sanctum Linn., and Psidium guajava L. in the inhibition/induction of hepatic and intestinal cytochrome P450 (CYPs) and Phase-II conjugated drug metabolizing enzymes (DMEs). Consumption of these herbal remedy has been ...

This study demonstrates that carbohydrates play an essential role in sperm-egg interactions in birds. Sperm-egg interaction was measured in vitro as the ability of spermatozoa to hydrolyse a small hole in the inner perivitelline layer, the equivalent of the mammalian zona pellucida. Preincubation with Triticum vulgaris lectin (WGA) and succinyl-WGA (S-WGA) at 10 microgram ml(-1) resulted in com...