An efficient, simple, and green four-component reaction for synthesizing 1,2,4,5-tetrasubstituted imidazoles is developed. In present work exploring the use of Samarium triflate as a heterogeneous catalyst aldehydes, aromatic amines, benzil, ammonium acetate. The current approach offers many advantages, such excellent yields, shortening time, reusability catalyst, mild conditions.

This is a study of a small group of patients with rheumatoid arthritis, in whom the urine excretion of imidazole compounds was examined by Figlu assay and chromatography of 12-hour urine collections following 15 g. histidine load, and by assay of 4 amino-imidazole-5 carboxamide (AIC) in 12hour urines with and without histidine load. Gough, McCarthy, Read, Mollin, and Waters (1964) found low ser...

Trisubstituted benzimidazoles have demonstrated potency against Gram-positive and Gram-negative bacterial pathogens. Previously, a library of novel trisubstituted benzimidazoles was constructed for high throughput screening, and compounds were identified that exhibited potency against M. tuberculosis H37Rv and clinical isolates, and were not toxic to Vero cells. A new series of 2-cyclohexyl-5-a...

M06-2X/6-31+G(d,p) computations are reported for the 8π-6π electrocyclization cascades of 1,3,5,7-tetraenes. The rate-determining step for these cascades is typically the second (6π) ring closure. According to experiment and theory, un- and monosubstituted tetraenes readily undergo 8π electrocyclic ring closure to form 1,3,5-cyclooctatrienes; however, the 6π electrocyclizations of these cyclooc...

Rhodococcus equi and species of Nocardia and Gordonia may be human opportunistic pathogens. We find that these, as well as several isolates from closely related genera, are highly susceptible to the imidazoles bifonazole, clotrimazole, econazole, and miconazole, whose MICs are </=1 micro g/ml. In liquid cultures 1 micro g of the drug/ml was bacteriostatic and 10 micro g/ml was bactericidal. On ...

Stereodefined enol derivatives of aldehydes are prepared from terminal alkynes. Specifically, terminal alkynes are known to undergo Cp2ZrCl2-catalyzed methylalumination. Here, we show that the resultant vinylalanes can be oxygenated with peroxyzinc species to generate trisubstituted enolates. Electrophilic trapping with carboxylic anydrides or silyl triflates yields trisubstituted enol esters o...

Herein we report the first example of Pd-catalyzed highly selective three-component reaction alkyn-1,4-diol dicarbonates, organoboronic acids, and malonate anions for efficient synthesis trisubstituted 2,3-allenyl malonates not readily...

warded as a promising molecule because of its broad spectrum pharmacological activities like antitubercular, antibacterial, antifungal, anticancer, anti-HIV, anthelmintic, anti-inflammatory and antihypertensive activities. Imidazoles are one of the oldest and potent heterocyclic compounds having antimicrobial activities. Structure activity relationship studies of quinazolinone ring system revea...

The presence of free fatty acids in liposome model membranes sensitizes these membranes to the action of the imidazole antifungals, clotrimazole, micronazole, and sulconazole. Unsaturation of the fatty acids is an important variable; the effect of linoleic and oleic acids is much greater than that of stearic acid. The imidazoles differ somewhat in action, with clotrimazole potency greatest both...