Cisplatin is one of the most commonly used therapeutic drugs for cancer therapy, yet prolonged cisplatin treatment frequently results in drug resistance. To enhance therapeutic effect of cisplatin, we conducted a high throughput screening using a kinase library containing 704 kinases against triple negative breast cancer (TNBC) cells. We demonstrated that cisplatin activates ATR, CHK1 and WEE1,...

Abstract We propose a triple-star scenario where the merger of two pre-main-sequence low-mass stars, ?0.5 M ? , ejects dusty equatorial outflow that obscures and temporarily causes disappearance massive star, ?8 . The inner binary powers faint outburst, i.e., intermediate luminosity optical transient (ILOT), but its main effect can last for decades is to (almost) disappear luminous star triple ...

To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some N-alkyl-4-(1H)-quinolones bearing position 2 alkynyls with various chain length and triple bond positions were prepared and tested for in vitro antibacterial activity against rapidly-growing strains of mycobacteria, the vaccine strain Mycobacterium bovis BCG, ...

The rotational dynamics of 2-ethylnaphthalene have been studied using subpicosecond transient grating optical Kerr effect techniques. Both the neat liquid and a series of dilutions in carbon tetrachloride were examined, The neat liquid was studied over a temperature range of 2-100 OC, and the 1 M solution was studied from -30 to +25 OC. After ultrafast librational dynamics have decayed, there r...

AIM Glioblastoma (GBM) is one of the lethal central nervous system tumors. One of the widely used chemical agents for the treatment of glioblastoma is temozolomide. It is an orally administered, deoxyribonucleic acid (DNA) alkylating agent. DNA alkylation triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage and thus lower the therapeutic effect...

Soft errors induced by radiation, causing anomalies in satellite equipment and spacecrafts, have become one of the most challenging issues that impact the reliability of modern processors even in ground-level applications. In this work, we investigate the feasibility of using ARM Cortex-R4 CPU for space and avionics applications. We create a single-event upset and transient tolerant variant Cor...

BACKGROUND AND AIM Metronidazole and tetracycline-based second-line quadruple therapy, widely used for Helicobacter pylori infection, often ends up in failure due to antibiotic resistance and poor compliance in Korea. Our aim is to evaluate the efficacy and tolerability of moxifloxacin-based triple therapy as an alternative second-line treatment for H. pylori infection. METHODS The subjects c...

BACKGROUND Non-invasive procedures such as acoustic radiation force impulse imaging (ARFI) shear-wave elastography are currently used for the assessment of liver fibrosis. In the course of chronic hepatitis C, significant liver fibrosis or cirrhosis develops in approximately 25% of patients, which is a negative predictor of antiviral treatment response. Cirrhosis can be prevented by successful ...