Matricellular proteins play multiple roles in primary tumor growth, local invasion and tumor angiogenesis. However, their contribution to metastasis and the putative mechanisms involved are less well characterized. In ER-negative human breast cancer, elevated expression levels of the matricellular protein Cysteine-rich angiogenic inducer 61 (CYR61) are associated with more aggressive progressio...

background: triple-negative breast cancers (tnbc) have a more aggressive course and are associated with poorer prognosis in comparison with other subtypes of breast cancer. one of the most common subtypes of tnbc is basal-like. the aim of this study was to investigate clinicopathological characteristics and clinical course of tnbc in iranian women and compare them with other studies. subjects a...

introduction: triple negative breast cancers (tnbc) have a more aggressive course and are associated with poorer prognosis in comparison with other subtypes of breast cancer. one of the most common subtypes of tnbc is basal-like. the aim of this study was to investigate clinicopathological characteristics and clinical course of tnbc in iranian women and compare it with other studies. method: be...

context triple negative breast cancer (tnbc) is a heterogeneous group of diseases that is negative for esterogen receptor (er) progesteron receptor (pr) and human epidermal growth factor receptor 2 (her2). this type of breast cancer is typically high-grade carcinomas, although low-grade tumors occur. the aim of this review is to focus on molecular classification and features, prognostic markers...

OBJECTIVES To assess whether long-term users of intracavernous (IC) injections after radical prostatectomy can switch to oral therapy with sildenafil citrate. METHODS Forty-nine patients (mean age 60.9 years) with erectile dysfunction after radical prostatectomy were identified as long-term users of IC injections (3.7 +/- 1.9 years). These patients received open-label treatment with sildenafi...

BACKGROUND Although the survival benefits of antiretroviral therapy (ART) for the treatment of HIV infection are well established, the clinical management of HIV disease continues to present major challenges. There are particular concerns regarding access to appropriate HIV treatment among HIV-infected injection drug users (IDU). METHODS In a prospective cohort study of HIV-infected IDU in Va...

Abstract Background Triple-negative breast cancer (TNBC) is a kind of aggressive with high rate metastasis, poor overall survival time, and low response to targeted therapies. To improve the therapeutic efficacy overcome drug resistance TNBC treatments, here we developed cell membrane-coated oxygen delivery nanoprobe, CCm–HSA–ICG–PFTBA, which can hypoxia at tumor sites enhance photodynamic ther...

Background To compare the pregnancy outcomes after two embryos versus three embryos transfers (ETs) in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. MaterialsAndMethods This retrospective study was performed on three hundred eighty seven women with primary infertility and with at least one fresh embryo in good quality in order to transfer at each ...

BACKGROUND Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and shifts the phenotype from mesenchymal to epithelial (MET) in the DMBA-induced mammary tumor model. This study describes the effect of HBOT on tumor growth, angiogenesis, chemot...