Introduction: Heart failure is a major hazard for public health. Despite recent advance in medical therapy, there is not enough information on the outcome of off-pump coronary artery bypass (OPCAB) and medical therapy on the patients with severe ventricular dysfunction and triple-vessel (CAD). This study aimed to compare treatment outcomes and mortality rate in patients undergoing off-pump coro...

Abstract Background Anti-angiogenic therapy has been widely applied to the clinical treatment of malignant tumors. However, efficacy such treatments called into question, especially in triple-negative breast cancer (TNBC). Bevacizumab, first anti-angiogenic agent approved by FDA, actually increases invasive and metastatic properties TNBC cells, resulting from activation Wnt/?-catenin signaling ...

Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic and huge burden to healthcare systems worldwide. One of the characteristic symptoms COVID-19 is asymptomatic hypoxemia, also called happy hypoxia, silent or hypoxemia. Patients with hypoxemia often have no subjective symptoms, such as dyspnea, even though judged objectiv...

BACKGROUND In a clinical study, the role of chronic hypoxia in patients with chronic obstructive pulmonary disease or the role of transient hypoxia in patients with obstructive sleep apnea syndrome were examined for the peripapillary retinal nerve fiber layers. PATIENTS AND METHODS 10 patients with chronic obstructive pulmonary disease GOLD stages 3 or 4 (4 men and 6 women, age 47 to 71 years...

introduction: heart failure is a major hazard for public health. despite recent advance in medical therapy, there is not enough information on the outcome of off-pump coronary artery bypass (opcab) and medical therapy on the patients with severe ventricular dysfunction and triple-vessel (cad). this study aimed to compare treatment outcomes and mortality rate in patients undergoing off-pump coro...

The congenital polycythemic disorders with elevated erythropoietin (Epo) have been until recently an enigma, and abnormality in the hypoxia-sensing pathway has been hypothesized as a possible mechanism. The tumor suppressor von Hippel-Lindau (VHL) participates in the hypoxia-sensing pathway, as it binds to the proline-hydroxylated form of the hypoxia-inducible factor 1alpha (HIF-1alpha) and med...

N=number of women having triple test; p=prevalence of Down's syndrome; p*N=total number of fetuses with Down's syndrome; DR=detection rate; FPR=false positive rate; p*N*DR*AR=number of women with true positive results who have amniocentesis; (1-p)*N*FPR*AR=number of women with false positive results who have amniocentesis; p*N*DR*AR=number having an abortion (all positive amniocentesis results)...