background: previous studies have reported the antifertility activities of sulfonamides. this study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats. methods: a total of 54 rats were randomly divided into 9 groups (n=6) . group i served as the control and group ii (vehicle) received saline. other groups, iii to ix,...

Brucellosis is still a common disease in many developing countries, particularly among farm workers, abattoir workers, and veterinarians, as well as those who rear sheep and camels. Similarly, the disease is prevalent among those who are in the habit of drinking fresh unpasteurized camel or goat milk (4). In Saudi Arabia it contributes substantially to ill health and outpatient visits (3). In o...

Salmonella typhi is the main cause of enteric fever in Homo sapiens. The topic concern now a day emerging multidrug resistance. It causes disease intestinal tract known as fever, while paratyphi paratyphoid fever. This infection waterborne and foodborne. Approximately 12 – 33 million people suffered from typhoid annually around globe. Objective: aim study was to evaluate sensitivity patterns pa...

Introduction Co-trimoxazole is an antibacterial combination of trimethoprim and sulphamethoxazole which acts by sequentially blockading folate metabolism (Elion, Singer & Hitchings, 1954; Darrell, Garrod & Waterworth, 1968). Cases of haematological toxicity have been reported following its use in patients with initially normal haematological status (Kahn, Fein & Brodsky, 1968; Paulley, 1970; Mc...

In the past decade the importance of non-O1 and non-O139 strains of Vibrio cholerae has been highlighted globally. This study aimed to evaluate the frequency and antimicrobial susceptibility profile of non-O1 and non-O139 V. cholerae in Pakistan. Data of stool specimens yielding growth of non-O1 and non-O139 V. cholerae isolated at a national referral laboratory from 1999 to 2012 were retrospec...

The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infecting organisms were equivalent in both groups of patients. Escherichia coli wa...

A patient is described in whom there was strong circumstantial evidence of an interaction between warfarin and co-trimaxazole. To test the validity of this hypothesis a series of in vitro and in vivo human studies were untaken. The results indicate that interaction may occur in which the sulphamethoxazole moiety of co-trimoxazole displaces warfarin from its binding sites on plasma albumin. Neve...