Using Ag2CO3 as an additive, we developed the Pd-catalyzed intermolecular C-H/C-H cross-coupling of pyridine N-oxides with five-membered heterocycles such as 1-benzyl-1,2,3-triazoles, thiophens and furans. This protocol provides an efficient and regioselective approach for the synthesis of unsymmetrical biheteroaryl molecules.

A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy.

Cancer is one of the most feared and dreaded diseases across world. In clinical practice, a variety anticancer agents natural, semi-synthetic synthetic origin exist, but they suffer from side effects drug resistance, so are insufficient to combat disease. Coumarins bicyclic benzene-pyrone-fused phytomolecules with wide range biological effects, including powerful activity on numerous cell lines...

Functional and condensed derivatives of 1,2,4-triazoles are mostly used as biologically active compounds, modern studies increasingly report their successful use surfactants, stabilizers for the formation nanoparticles, components hybrid perovskites, which promising materials opto-electronics.
 Synthesis new [1,3]thiazolo[3,2-b][1,2,4]triazol-7-ium salts containing a long-chain heptadecyl ...

BACKGROUND Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, an environmental route of resistance development has been suggested through exposure to 14α-demethylase inhibitors (DMIs). The main resistance mechanism associated with this putative fun...

1,2,3-triazoles, the corresponding triazolium salts, and resulting mesoionic carbenes (MICs) of 1,2,3-triazol-5-ylidene type are at forefront contemporary research. In this contribution, we present a comprehensive study involving eight triazoles, seventeen two silver(i)- four gold(i)-MIC complexes. The substituents on N1-atom heterocycles either ferrocenyl or phenyl those C4-atom bear various a...