Abbreviations: BC: Bladder Cancer; MIBC: Muscle-Invasive BC; NMIBC: Nonmuscle-Invasive BC; BPH: Benign Prostatic Hyperplasia; CT: Computed Tomography; CEA: Carcinoembryonic Antigen; CA19-9: Carbohydrate-Antigen 19-9; HCC: Hepatocellular Carcinoma; TCC: Transitional Cell Carcinoma; UC: Urotherial Carcinoma; Hex: Hexose; Man: D-mannose; Gal: D-galactose; HexNAc: N-acetylhexsosamine; GlcNAc: N-ace...

Neoadjuvant chemotherapy in transitional-cell carcinoma of the bladder (TCC) improves survival. This is one of the most important developments in the management of muscle-invasive bladder cancer in recent times. There is an improved absolute 5-year survival of at least 5% for T2-T4 disease. To achieve this benefit, a cisplatin-containing combination is required. There is no difference in surviv...

Seung Il Jung, Ho Suck Chung, Chang Min Im, Sun-Ouck Kim, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu From the Department of Urology, Chonnam National University Medical School, Gwangju, Korea We report a case of a metachronous transitional cell carcinoma (TCC) of the penile urethra in an elderly male after nephroureterectomy. The patient had a history of right nephroureterectom...

PURPOSE The purpose of this study was to examine the tumor specificity, cytotoxicity, and granulocyte macrophage colony-stimulating factor expression of CG0070, a conditionally replicating oncolytic adenovirus, in human bladder transitional cell carcinoma (TCC) cell lines and determine its antitumor efficacy in bladder TCC tumor models. EXPERIMENTAL DESIGN Virus yield and cytotoxicity assays ...

Transitional cell carcinoma (TCC) of the urinary bladder is the most common cancer of the urinary tract. Most of the TCC cases are of the superficial type and are treated with transurethral resection (TUR). However, the recurrence rate is high and the current treatments have the drawback of inducing strong systemic toxicity or cause painful cystitis. Therefore, it would be of therapeutic value ...

Bladder cancer is one of the most common urological malignancies. Ninety percent of the bladder tumors are transitional cell carcinomas. The most important molecular mechanism in the development of carcinogenesis is the Deletions or inactivation of the cancer suppressor genes. Several suppressor gene loci have been closely associated with bladder cancer. These include p53 on chromosome 17p, ret...

INTRODUCTION The prognostic significance of PTEN protein loss in bladder cancer is not well established. The objective of this study was to investigate the PTEN expression profile in superficial noninvasive papillary transitional cell carcinoma (TCC) versus invasive TCC and compared the results with pathological and clinical parameters. MATERIALS AND METHODS Bladder tumor samples were obtaine...

Hematogenous metastasis to skeletal muscle from urothelial carcinoma is extremely rare and metastatic disease to skeletal muscle tends to be found in people with advanced-stage neoplasm. We report in this paper a case of left sartorius muscle metastasis from urothelial cell carcinoma. A left nephroureterectomy with bladder cuff excision was performed and revealed a high-grade papillary transiti...

OBJECTIVES Upper urinary tract transitional cell carcinoma (UUT-TCC) is a rare disease. Open nephroure-terectomy remains the gold standard for surgical treatment. We aim to evaluate the standing of novel surgical treatment in UUT-TCC. METHODS Extensive review of available literature on UUT-TCC, with emphasis in surgical treatment. English medical literature available in PubMed, Ovid, EMBASE y...

Sir, Paraneoplastic syndromes are defined as nonmetastatic systemic effects that accompany malignant disease. These syndromes may occur in up to 10-15% of malignancies. A few paraneoplastic syndromes have been reported in metastatic transitional cell carcinoma including hypercalcemia, thrombocytosis, eosinophilia, nephrotic syndrome, acanthosis nigricans, dermatomyositis, polymyositis, and leuk...