........................................................................................................................ 3 PREFACE ............................................................................................................................ 5 LIST OF ORIGINAL PUBLICATIONS....................................................................................... 9 ABBREVIATIONS .........

•Diabesity defines common metabolic features of central obesity and type 2 diabetes. •The iron implication in cardiometabolic risk has been suggested but poorly tested. conjoint action diabetes impairs status. •Low TSAT diabesity suggests inefficient transport for normal functions. low levels imply higher non-bound potential pro-oxidant effects. Aims The relationship between status, mellitus (T...

The behavior of rat transferrin has been investigated employing acrylamide gel electrophoresis and isoelectric focusing. In vitro trace labeling with iron chelates at 30 min was 93%-98% effective, whereas binding by simple ferric salts was reduced to 71%-76%. Complete and specific binding of 59FeSO4 by the iron binding sites of transferrin was demonstrated after in vitro or in vivo addition of ...

Atherosclerosis To the Editor: Juan and colleagues1 showed impressive data supporting the role of hemeoxygenase-1 (HO-1) in cytoprotective response and iron homeostasis. They demonstrated that gene transfer-mediated overexpression of HO-1 in vascular cells could facilitate iron metabolism and attenuate atherogenesis in mice prone to develop premature and severe atherosclerosis. It is believed t...

Because of uncertainty as to the molecular weight of transferrin, a previous comparison [Von der Heul et al., Clin. Chim. Acta 38, 347 (1972)] between transferrin content of serum and total iron-binding capacity cannot be definitive. We found a conversion factor for expressing the maximum amount of iron bound by 1 mg of transferrin. We compared the resulting calculated value with values obtaine...

To determine whether the hypoferremic response to inflammation requires neutrophils, we administered human recombinant IL-1 to mice made neutropenic with cyclophosphamide. With single intraperitoneal injections of IL-1 the plasma iron concentrations decreased significantly in mice with either normal neutrophil counts or neutropenia. After single injections transferrin concentrations were not si...