The complexation behavior of a series of paraquats (G1.2PF(6)-G5.2PF(6)) and bis(pyridinium) derivatives (G6.2PF(6)-G14.2PF(6)) with pillar[5]arene (P5A) host has been comprehensively investigated by (1)H NMR, ESI mass and UV-vis absorption spectroscopy. It is found that P5A forms 2 : 1 external complexes with N,N'-dialkyl-4,4'-bipyridiniums (G1-G4.2PF(6)); while it forms 1 : 1 pseudorotaxane-t...

This paper describes a detailed study on the complexation of pyridinium derivatives with calixarenes bound to gold nanoparticles (AuNPs). The studied calixarene derivatives are mixed with alkanethiols to formmixed monolayers on AuNP surfaces. The key findings are: (i) even a small amount (less than 11 mol%) of calixarenes can retain their complexation abilities among a majority of alkanethiols ...

paracetamol is a sparingly soluble bitter tasting drug. it is widely used as an analgesic and antipyretic. complexation of drug with different cyclodextrins (?, ? and hp-?-cd) was attempted to improve solubility of paracetamol. during the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of paracetamol w...

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...

The complexation abilities of five cyclodextrins (CDs) with seven phenylpropanoids (PPs) were evaluated by UV-visible spectroscopy, phase solubility studies and molecular modeling. Formation constants (K f), complexation efficiency (CE), PP:CD molar ratio, increase in formulation bulk and complexation energy were assessed. All complexes exhibited a 1:1 stoichiometry but their stability was infl...

purpose of this study was to investigate the effect of the presence of the water soluble polymers viz hpmc, pvp and peg 6000 on aqueous solubility and complexation abilities of felodipine with or without presence of β-cyclodextrin (βcd) and hpβcd by phase solubility studies. the data revealed the initial increase in drug solubility followed by plateau in the presence of relatively low polymer c...

Poor aqueous solubility of anticancer drug, albendazole (ABZ), prevents parenteral application. Here, we demonstrate how to increase the aqueous solubility of ABZ to 6- 8 mg/ml using sulfobutylether - β-cyclodextrin (SBE-β-CD) or Hydroxypropyl- β-cyclodextrin (HP- β-CD) by manipulation of complexation parameters such as the physical state of ABZ (ionized in acetic acid), the concentration of io...

The effects of natural organic matter (NOM), ferrozine, and AQDS (anthraquinone-2,6-disulfonate) on the reduction of hematite (alpha-Fe2O3) by Shewanella putrefaciens CN32 were studied. It has been proposed that NOM enhances the reduction of Fe(III) by means of electron shuttling or by Fe(II) complexation. Previously both mechanisms were studied separately using "functional analogues" (AQDS for...