Objective(s): Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in commercial food additives and cosmetics worldwide. Uptake of these nanoparticulate into humans by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. Thus, the present study designed to evaluate the toxic effect of mixed rutile and anatase TiO2 NPs on serum bioc...

This study describes the functional characterization of a specific mosquito transaminase responsible for catalyzing the transamination of 3-hydroxykynurenine (3-HK) to xanthurenic acid (XA). The enzyme was purified from Aedes aegypti larvae by ammonium sulfate fractionation, heat treatment, and various chromatographic techniques, plus non-denaturing electrophoresis. The purified transaminase ha...

INTRODUCTION Liver injury is a frequent complication associated with anorexia nervosa, and steatosis of the liver is thought to be the major underlying pathology. However, acute hepatic failure with transaminase levels over 1000 IU/mL and deep coma are very rare complications and the mechanism of pathogenesis is largely unknown. CASE PRESENTATION A 37-year-old Japanese woman showed features o...

PURPOSE We previously demonstrated liver- and lobe-selective gene transfer following instillation of plasmid DNA (pDNA) onto the liver surface in mice. Safety concerns must be resolved prior to future clinical use. Thus, we investigated safety of liver surface instillation of pDNA in normal and hepatitis mice. METHODS pDNA was instilled onto the liver surface in normal and carbon tetrachlorid...

Bovine liver mitochondria have been found to contain an enzyme which will catalyze the formation of &aminolevulinic acid via a transamination reaction rather than via the condensation of glycine and succinyl coenzyme A. The enzyme, L-alanine:y,bdioxovaleric acid aminotransferase (y,&dioxovalerate transaminase) was isolated and purified to apparent homogeneity. y,&Dioxovalerate transaminase is q...