Phoslactomycins (PLMs), exemplified by PLM B (Figure 1), are a unique class of antitumor, antiviral, and antifungal polyketide natural products.1,2 The antitumor activity of PLMs is attributed to a potent and selective inhibition of protein Ser/Thr phosphatase 2A (PP2A).3 The PLM biosynthetic gene cluster from Streptomyces sp. HK803 has been cloned and sequenced.4 The PLM polyketide synthase (P...

The synthesis of extended dicationic bis-benzimidazoles starting from trans-1,2-bis(4-cyanophenyl)ethene and trans-1,2-bis(4-cyanophenyl)cyclopropane is reported. The target diamidines show significant in vitro activity against B. subtilis.

Objectives: The objective of this research was to investigate the chemical composition and antibacterial activities of the fatty acids and essential oil from various parts of Ligularia persica Boiss (L. persica) growing wild in north of Iran. Materials and Methods: Essential oils were extracted by using Clevenger-type apparatus. Antibacterial activity was tested on two Gram-positive and two Gra...

Two modern laser-based techniques were synchronously applied to study the dynamics of the trans-resveratrol activity in Botrytis cinerea-infected grapes. Direct analysis of trans-resveratrol in both infected and noninfected grapes (Vitis vinifera, Aledo variety) was performed by using an analytical technique incorporating laser desorption coupled with laser resonant ionization and time-of-fligh...

We have investigated the functional organization of the Abdominal-B gene in the bithorax complex using the expression of the Ultrabithorax gene as an assay for Abdominal-B trans-regulatory functions. Using Polycomb mutants to relax the normal spatial control of Ultrabithorax expression, we have examined the effects of Abdominal-B mutations on the expression of Ultrabithorax protein products in ...

Metabolism of vitamin A, all-trans-retinol, leads to the formation of 11-cis-retinaldehyde, the visual chromophore, and all-trans-retinoic acid, which is involved in the regulation of gene expression through the retinoic acid receptor. Enzymes and binding proteins involved in retinoid metabolism are highly conserved across species. We previously described a novel mammalian enzyme that saturates...

The title compound, C24H30O7, is a diterpenoid isolated from the seeds of Caesalpinia minax. It consists of two cyclo-hexane rings (A and B), one unsaturated six-membered ring (C) and one furan ring (D). The stereochemistry of the ring junctures is A/B trans and B/C trans. Rings A and B have normal chair conformations while C adopts a twisted half-chair conformation due to fusion to the furan r...

Oranges and mandarins in Chongqing, China, are mostly processed for juice their peels wasted or landfilled. To add value, it is essential to utilize the extract useful materials, such as citrus oils (CEOs). Here, we report metabolome analysis of Citrus x sinensis (CS) reticulata (CR). In total, 793 metabolites were detected CS CR peels, which 242 differentially accumulated. The grouped into 12 ...

HS-SPME-GC–MS analysis of the scent Dactylorhiza viridis revealed presence verbenone (28.86%), caryophyllene (25.67%), β-terpineol (9.48%), and δ-cadinene (6.94%). In romana β-ocimene (18.69%), pentadecane (18.40%), α-farnesene (14.65%), isopropyl 14-methylpentadecanoate (14.32%) were found. incarnata contained tetradecane (11.07%), (28.40%), hexadecane (19.53%), heptadecane (17.33%), α-cubenen...