Previously, (-)-trans-1-phenyl-3-N,N-dimethylamino-1,2,3,4-tetrahydronaphthalene ([-]-trans-H(2)-PAT) was shown to activate stereospecifically histamine H(1) receptors coupled to modulation of tyrosine hydroxylase activity in guinea pig and rat forebrain in vitro and in vivo. Furthermore, the novel radioligand [(3)H](-)-trans-H(2)-PAT was shown to label selectively H(1) receptors in guinea pig ...

The rotational spectrum of trans-cinnamaldehyde ((E)-3-phenyl-2-propenal, C9H8O) was recorded by chirped-pulse Fourier transform microwave spectroscopy in the frequency range of 2-8.5 GHz. The odourant molecule is the essential component of cinnamon oil and causes the characteristic smell. The rotational signatures of two conformers were observed: s-trans-trans- and s-cis-trans-cinnamaldehyde. ...

An undescribed phyllocoumarin-3-O-α-L-rhamnopyranoside 8 together with catechin 1, catechin-3-O-α-L-rhamnopyranoside 2, catechin-[7,8-bc]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 3, 5-O-trans-p-coumaroylquinic acid 4, trans-p-coumaric 5, catechin-[5,6-e]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 6, catechin-[5,6-e]-4α-(3,4-dihydroxyphenyl)-dihydro-2(3H)- pyranon 7, phyllocoumarin 9 a...

PURPOSE The purpose of this study was to investigate the predictability of pretreatment values including Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) derived parameters (K(trans), K(ep) and V(e)), early changes in parameters (K(trans), tumor volume), and heterogeneity (standard deviation of K(trans)) for radiation therapy responses via a human colorectal cancer xenograft model...

A selective trans-packaging system was developed to produce and isolate bovine viral diarrhea virus (BVDV) pseudo-particles with complementing reporter replicons and their packaging proteins expressed in trans with recombinant vaccinia virus. The encapsidation of replicon rNS3-5B was dependent not only on the in trans expression of structural proteins C, E(rns), E1 and E2, but also the nonstruc...

The 351.1 nm photoelectron spectrum of the peroxyacetate anion, (CH(3)C(O)OO(-)) was measured. Analysis of the spectrum shows that the observed spectral features arise almost exclusively from transitions between the trans-conformer of the anion and the X(2)A'' and A (2)A' states of the corresponding radical. The electron affinity of trans-CH(3)C(O)OO is 2.381+/- 0.007 eV and the term energy spl...

mRNA maturation in Trypanosoma brucei depends upon trans splicing, and variations in trans-splicing efficiency could be an important step in controlling the levels of individual mRNAs. RNA splicing requires specific sequence elements, including conserved 5' splice sites, branch points, pyrimidine-rich regions [poly(Y) tracts], 3' splice sites (3'SS), and sometimes enhancer elements. To analyze ...

This study reports pharmacological and physiological effects of cis- and trans-(3-aminocyclopentanyl)butylphosphinic acid (cis- and trans-3-ACPBPA). These compounds are conformationally restricted analogs of the orally active GABA(B/C) receptor antagonist (3-aminopropyl)-n-butylphosphinic acid (CGP36742 or SGS742). cis-[IC(50)(rho1) = 5.06 microM and IC(50)(rho2) = 11.08 microM; n = 4] and tran...

The (13)C- and (1)H- NMR spectra of isopropyl N-dodecanoylsarcosinate (SLIP) were measured in CDCl(3), CD(3)OD and in sodium dodecanoylsarcosinate (Sar) aqueous solution. The existence of both cis and trans isomeric forms are observed for SLIP just as for Sar. The trans/cis ratio of SLIP in a dilute CDCl(3) solution is over 3.2, which is indicating that SLIP-trans conformation is more stable in...