A novel methodology for the α-vinylation of amides with arylacetylenes under metal-free conditions has been introduced. This methodology provides a new protocol to synthesize allylamines. In each product, the amount of the cis-isomer was more than that of the trans-isomer.

A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hy...

Under physiological conditions, the trans-presentation of interleukin-15 (IL-15) by the IL-15 receptor α on the cell surface allows to confine and tune the IL-15-mediated immune responses. Therefore, targeting strategies that mimic this situation at the tumor sites appear especially promising for anticancer immunotherapy.

Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response. The inflammatory process is related to a variety of immune cells, including macrophages, helper T cells, neutrophils, dendritic cells, and Treg cells, and is associated with proinflammatory, chemotactic and regulatory cytoki...

N-Phosphonate terminal aziridines undergo lithium 2,2,6,6-tetramethylpiperidide-induced N- to C-[1,2]-anionic phosphonyl group migration under experimentally straightforward conditions, to provide a stereocontrolled access to synthetically valuable trans-α,β-aziridinylphosphonates. The utility of this chemistry has been demonstrated in the asymmetric synthesis of a β-aminophosphonate.

In this paper, we study half lightlike submanifolds M of an indefinite generalized Sasakian space form M̄(f1, f2, f3), with an indefinite trans-Sasakian structure of type (α, β), subject to the condition that the structure vector field of M̄ is tangent to M . Our main result is a characterization theorem for such a half lightlike submanifold. Mathematics Subject Classification: 53C25, 53C40, 53C50

Neuronal exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Before fusion, SNARE proteins form complexes bridging the membrane followed by assembly toward the C-terminal membrane anchors, thus initiating membrane fusion. After fusion, the SNARE complex is disassembled by the AAA-ATPase N-ethylmaleimide-sensitive factor that requires...

NMR experiments (transferred NOE and Saturation Transfer Difference) were used to shed light on the binding epitope of RGD peptidomimetics 1-3 with integrins αvβ3 and α(IIb)β3, expressed on the membrane of ECV304 bladder cancer cells and human platelets, respectively. The NMR results were supported by docking calculations of 1-3 in the active sites of αvβ3 and α(IIb)β3 integrin receptors and we...

The change of essential oil ratios and components five different basil genotypes harvested at times (00:00, 06:00, 12:00, 18:00) in day was investigated. Plants were grown under the field conditions oils plants extracted by hydro-distillation method. Identification performed GC-MS. It G5 genotype that had highest content all plant parts, regardless time day. (2.8%) obtained from dry leaves samp...