* Results of this investigation were presented at the 43rd (June , 1973) Kinki Regional Meeting of Japanese Pharmacological Society. AbstractEffects of psychotropic drugs on intracranial self-stimulation behavior were investigated in rats with chronic electrodes implanted in the lateral posterior hypothalamus. Major tranquilizers such as chlorpromazine, levomepromazine, haloperidol, clozapine a...

STUDY OBJECTIVE To explore gender differences in morbidity and total health care utilization 5 years prior to diagnosis of obstructive sleep apnea (OSA). DESIGN Case-control study; patients were recruited between January 2001 and April 2003. SETTING Two university-affiliated sleep laboratories. PATIENTS 289 women (22-81 years) with OSA were matched with 289 men with OSA for age, body mass...

background and aims: diabetic nephropathy (dn) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. the aim of this study was to investigate new modalities for treatment of diabetic nephropathy. methods:this study was a mini-review research to investigate drugs that are used for dn treatment. results...

in this investigation wer studied the effect of dopaminergic system on the conflict behavior in rat, using vogel’s test. the related drugs were injected intraperitonealy (ip), and produced the following results:diazepam at doses of 0.5 and 1 mg/kg increased the lick –shock responses in the vogel’s thest. quinpirole (d2-agnosit), at doses of 0.1 and 10 mg/kg, increased the confict responses, whe...

rheumatoid arthritis is a chronic inflammatory disease characterized by the sequestration of various leukocyte subpopulations within both the developing pannus and synovial space. this study was undertaken to examine the therapeutic potency of tindurin in experimental rheumatoid arthritis. collagen-induced arthritis (cia) was induced by intradermally immunization of lewis rats at the base of th...

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

T seriousness of alcohol withdrawal and its widespread occur­ rence in the 166 Veterans Administration hospitals in the 1960’s was the principal reason this pivotal study was conducted. The important work by Kaim and colleagues has endured over the years, because alcohol withdrawal still is common, potentially life threatening, and often not recognized and treated promptly and effectively. Kaim...

background & aim: in recent years, complementary therapies deliver a medicinal drop named ‘dentol’ for pain controlling and tooth infection. according to the excessive consumption of chemical drugs and their side effects, the subject of human health and its development in society and the level of awareness, insight and positive behavior of people and also dentists as the trustees of the soc...

case: a 26-year-old man referred to emergency service with coma, bradypnea (respiratory rate = 4 breaths per minute) and pinpoint pupil. on chest auscultation, diffuse coarse crackle and on abdominal auscultation, decrease of abdominal sounds were found. at first evaluation, pulse oximetry showed 19% saturation of oxygen. after oxygen therapy with facial mask and infusion of 8.4 mg naloxone in ...

conclusions in psychoactive substance dependents, serum routine biochemistry parameters can be used to predict the need for intensive monitoring and treatment programs. results there was a statistically significant difference in the gamma-glutamyl transferase (ggt), uric acid, creatinine, urea, albumin, aspartate aminotransferase (ast) medians between the dependent and control groups (p < 0.05)...