BACKGROUND We asked whether tranexamic acid (TXA) administration could reduce blood loss and blood transfusion requirements after simultaneous bilateral total knee arthroplasty (TKA). This study examined the role of a novel method of TXA administration in TKA. METHODS TXA was administered as a bolus dose of 15 mg/kg 10 min before the inflation of the tourniquet on the first side. This was fol...

BACKGROUND Tranexamic acid (TXA) is well-established as a versatile oral, intramuscular, and intravenous (IV) antifibrinolytic agent. However, the efficacy of IV TXA in reducing perioperative blood transfusion in spinal surgery is poorly documented. METHODOLOGY We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-randomized (qi-RCTs) trials that included patients for ...

We conducted a systematic review and meta-analysis of randomised controlled trials evaluating the effect of tranexamic acid (TXA) upon blood loss and transfusion in primary total knee replacement. The review used the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group. A total of 19 trials were eligible: 18 used intravenous administration, one also evaluated ora...

Background: Postoperative seroma and haematoma are two of the most common complications follow-ing large surface area surgeries. A review literature was performed to evaluate evidence for use tranexamic acid in reducing postoperative formation breast surgery body contouring surgery. Methods search using MEDLINE, Cochrane Database Systematic Review, Central Register Controlled Trials (CENTRAL), ...

Kelmer, E. 94 IntRoduCtIon Bleeding is commonly encountered in critically ill veterinary and human patients. Blood products are increasingly used in veterinary medicine, however their use is not risk-free, and is often limited by low availability and high cost of blood components. Potential adverse effects of blood component therapy include immune and non-immune transfusion reactions, such as h...

Introduction: Bleeding during functional endoscopic sinus surgery (FESS) is an important issue for both anesthesiologists and surgeons as it can affect the safety and efficiency of the procedure. We compared the efficacy of tranexamic acid (TXA) and clonidine in reducing blood loss and improving surgical field visualization during FESS.   Materials and Methods: In a double-blind, randomized...

BACKGROUND Although randomized controlled trials have confirmed oral tranexamic acid (TXA) can provide similar blood-sparing efficacy compared with intravenous (IV) TXA in total knee arthroplasty (TKA), some concerns do remain about thromboembolic events after such systemic administration. Many studies have confirmed that intra-articular (IA) application of TXA can show similar blood-saving eff...

Objectives: It is aimed to investigate the effect of tourniquet and tranexamic acid (TXA) on amount perioperative bleeding in patients undergoing total knee arthroplasty. Methods: One hundred ninety-three included study. The study were divided into 4 groups. Group 1 (n = 78) was determined as patient group with long-term application, but without additional application accepted control group. 2 ...

BACKGROUND Tranexamic acid (TXA) is an antifibrinolytic agent that reduces blood loss during surgery, decreases mortality in civilian and military trauma populations, was adopted for prehospital use by the British military, and is now issued to U.S. Special Operations Forces for use on the battlefield. OBJECTIVE This study tested whether storage of TXA ampoules at four temperatures (-20°C, 4°...

BACKGROUND Topical tranexamic acid (TXA) has been shown to be effective in reducing blood loss and the need for transfusion after total knee arthroplasty. However, the effectiveness of topical TXA use in total hip arthroplasty (THA) still remains unclear. The purpose of this meta-analysis is to examine the safety and efficacy of topical use of TXA following THA. HYPOTHESIS Topical TXA reduces...