The time-independent elastic properties of trabecular bone have been extensively investigated, and several stiffness-density relations have been proposed. Although it is recognized that trabecular bone exhibits time-dependent mechanical behaviour, a property of viscoelastic materials, the characterization of this behaviour has received limited attention. The objective of the present study was t...

The effect of long-term treatment with the bisphosphonate zoledronate on vertebral bone architecture was investigated in estrogen-deficient mature rats. 4-month-old rats were ovariectomized and development of cancellous osteopenia was assessed after 1 year. The change of bone architectural parameters was determined with a microtomographic instrument of high resolution. After 1 year of estrogen-...

background: engineering new bone tissue with cells and a synthetic extracellular matrix represents a new approach for the regeneration of mineralized tissues compared with the transplantation of bone (autografts or allografts). methods: in this study, to mimic the mineral and organic component of natural bone, hydroxapatite (ha) and gelatin (gel) composite scaffolds were prepared. the raw mater...

OBJECTIVE The literature shows that bone mineral density (BMD) and the geometric architecture of trabecular bone in the femur may be affected by inadequate dietary intake of Mg. In this study, we used microcomputed tomography (micro-CT) to characterize and quantify the impact of a low-Mg diet on femoral trabecular bones in mice. MATERIALS AND METHODS Four-week-old C57BL/6J male mice were rand...

The purposes of the present study were to differentiate the effects of pre-surgery treatment with risedronate and post-surgery treatment with a reduced dosing frequency of risedronate on trabecular bone loss in ovariectomized rats and to determine whether post-surgery treatment with a reduced dosing frequency of risedronate would have a beneficial effect on trabecular bone loss after pre-surger...

Positive role of niacin on serum lipid profile of rats treated with glucocorticoids (GCs) has been reported. This study aims to evaluate effect of niacin on bone changes in GC-induced dyslipidemic rats. A number of 28 growing rats divided into four groups and treated as control, Methyl prednisolone (MP) group (3.5 mg/kg five days a week, SC); MPN group (MP + niacin 200 mg/kg/day orally) and MPA...

An abnormal remodelling process of bones can lead to various bone disorders, such as osteoporosis, making them prone fracture. Simulations load-induced trabecular were used investigate its response mechanical signal. However, the role mechanostat in trabecular-bone has not yet been investigated simulations underpinned by a longitudinal in-vivo study humans. In this work, finite-element model ba...

The shear strength of human trabecular bone may influence overall bone strength under fall loading conditions and failure at bone-implant interfaces. Here, we sought to compare shear and compressive yield strengths of human trabecular bone and elucidate the underlying failure mechanisms. We analyzed 54 specimens (5-mm cubes), all aligned with the main trabecular orientation and spanning four an...

Ultrasonic measuring technique is widely using for diagnosis of osteoporosis because of its safety. A precise simulation, however, is not reported, because the behavior of ultrasonic pulse propagated in a human bone is very complicated. In this paper, ultrasonic pulse propagation in bone phantom is analyzed using elastic Finite Difference Time Domain (FDTD) method. This proposed method treats n...

We introduce a continuous modeling approach which combines elastic responds of the trabecular bone structure, the concentration of signaling mole-cules within the bone and a mechanism how this concentration at the bone surface is used for local bone formation and resorption. In an abstract setting bone can be considered as a shape changing structure. For similar problems in materials science ph...