We present the case of a 62-years-old male, diabetic, in treatment with metformin, who was hospitalized because of jaundice and itching. He presented symptoms of jaundice the previous year. It was performed a cholangioRNM, a study of autoimmunity and hepatitis serology, but all these studies were normal. However, a hepatic hydatid cyst was detected and surgically operated. The patient had taken...

Botanicals have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver disease. Clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease. Basic scientific research has uncovered the mechanisms by which some plants afford their therapeutic effects. Silybum marianum (milk thistle) has...

Background: N-acetyl-p-aminophenol (APAP) or paracetamol overdose causes increasing of toxic metabolites, which disrupting hepatocyte function, and liver injury occurs. Curcumin has been used for treatment of inflammatory conditions such as hepatitis. Therefore, this study aims to determine effects of curcumin attenuate hepatitis in mice with APAP overdose. Methods: Male mice (25-30 gram) were ...

Botanicals have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver disease. Clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease. Basic scientific research has uncovered the mechanisms by which some plants afford their therapeutic effects. Silybum marianum (milk thistle) has...

Antibodies have been used for over a century in the prevention and treatment of infectious disease. They are used most commonly for the prevention of measles, hepatitis A, hepatitis B, tetanus, varicella, rabies, and vaccinia. Although their use in the treatment of bacterial infection has largely been supplanted by antibiotics, antibodies remain a critical component of the treatment of diptheri...

Pegvisomant (PEGv) is a growth hormone receptor antagonist approved for the treatment of acromegaly; one of its documented adverse effects is reversible elevation of hepatic enzymes. We report a 39-year-old male acromegalic patient with a pituitary macroadenoma who underwent transsphenoidal surgery. The patient's condition improved but GH and IGF-I levels did not normalize; as a consequence, we...

Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes disease. The Labrador retriever dog breed is a novel non-rodent model for copper-storage disorders carrying mutations in genes known to be involved in copper transport. Besides disease initiat...