1 Learning Goals 1. Be able to explain the difference between the p-value and a posterior probability to a doctor. 2 Introduction We have now learned about two schools of statistical inference: Bayesian and frequentist. Both approaches allow one to evaluate evidence about competing hypotheses. In these notes we will review and compare the two approaches, starting from Bayes formula. 3 Bayes for...

Patients who have had a transient ischaemic attack or nondisabling ischaemic stroke of presumed arterial origin have an annual risk of death from all vascular causes, non-fatal stroke, or non-fatal myocardial infarction that ranges between 4% and 11% without treatment. 2 In the secondary prevention of these vascular complications the use of aspirin has been the standard treatment for the past t...

Evolutionary partial differential actuations are usually solved by discretization in time and space, and by applying a marching in time procedure to data and algorithms potentially --2 parallelized in the spatial domain. In a cleparture from such a strictly. sequential temporal paradigm, we have developed the concept of tinle~~rgll~l__~~orithms, which allow -_..— the marching in time to be full...

We have developed a new combined approach for ab initio protein structure prediction. The protein conformation is described as a lattice chain connecting C(alpha) atoms, with attached C(beta) atoms and side-chain centers of mass. The model force field includes various short-range and long-range knowledge-based potentials derived from a statistical analysis of the regularities of protein structu...

INTRODUCTION The number of children less than 15 years estimated to be living with HIV globally approximated 3.2 million in 2013. Young people aged 15 to 24 years living with HIV approximated 4 million. The survival of these children and adolescents into adulthood poses new and urgent challenges of transition from the paediatric to adolescent to adult healthcare settings due to emerging develop...

The successful prediction of protein structure from amino acid sequence requires two features: an efficient conformational search algorithm and an energy function with a global minimum in the native state. As a step toward addressing both issues, a threading-based method of secondary and tertiary restraint prediction has been developed and applied to ab initio folding. Such restraints are deriv...

Coronary bifurcation lesions that involve significant side branches represent a particularly challenging subset of target lesions for percutaneous coronary interventions. Besides the necessity for the interventional cardiologist to often perform technically demanding interventions with more procedural steps, clinical outcome following percutaneous coronary intervention has usually been somewhat...

Patients who have had a transient ischaemic attack or nondisabling ischaemic stroke of presumed arterial origin have an annual risk of death from all vascular causes, non-fatal stroke, or non-fatal myocardial infarction that ranges between 4% and 11% without treatment. 2 In the secondary prevention of these vascular complications the use of aspirin has been the standard treatment for the past t...

We present a two-step variant of the \successive band reduction" paradigm for the tridiagonalization of symmetric matrices. Here we reduce a full matrix rst to narrow-banded form and then to tridiagonal form. The rst step allows easy exploitation of block orthogonal transformations. In the second step, we employ a new blocked version of a banded matrix tridiagonal-ization algorithm by Lang. In ...

64 British Journal of General Practice, January 2010 As to the second case, sections 30–33 create offences involving sexual activity with people suffering from a mental disorder (Box 2). The touchstone is ‘sufficient understanding of the nature or reasonably foreseeable consequences of what is being done ...’ This begs three crucial questions: what is sufficient?; sufficient for what? and; what...