Abstract Two major obstacles in brain cancer treatment are the blood-tumor barrier (BTB) and quiescent tumor cells. Here we show that Sox2+ cells directly project cellular processes to ensheathe capillaries medulloblastoma (MB), a process depends on mechanosensitive ion channel Piezo2. MB develops tissue stiffness gradient as function of distance capillaries. perceive substrate sustain local in...

catecholamine is a group of neurotransmitters that is believed to be responsible for the normal function of animal brain. physiological and behavioral changes of human body have been reported due to the damage of the brain function following lead exposure. due to the assumption of lead disposal in brain tissue with two year for its half-life, which results in alteration of brain function, we in...

There is an urgent need for treatments sporadic Alzheimer’s Disease (sAD). Although antibodies removing ß-amyloid have recently been shown to slow disease progression, the degenerative course continues. Thus, there a strategies that intervene early in process, before irreversible damage done neurons (e.g., by autophagic degeneration). This review will summarize evidence indicating targeting cal...

Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide. Despite extensive investigations over the past few decades, no effective therapies exist to improve the brain function in patients with TBI. Neural tissue engineering is an attractive therapeutic approach to restore the brain structure and function of damaged tissue. Bioactive motif of Stromal cell-deri...

OBJECTIVES Extremely preterm (EP) survivors have smaller brains, lower IQ, and worse educational achievement than their term-born peers. The contribution of smaller brain size to the IQ and educational disadvantages of EP is unknown. This study aimed (i) to compare brain volumes from multiple brain tissues and structures between EP-born (< 28 weeks) and term-born (≥ 37 weeks) control adolescent...

PURPOSE Human hypothalamic hamartomas (HHs) are associated with gelastic seizures, intrinsically epileptogenic, and notoriously refractory to medical therapy. We previously reported that the L-type calcium channel antagonist nifedipine blocks spontaneous firing and γ-aminobutyric acid (GABA)(A)-induced depolarization of single cells in HH tissue slices. In this study, we examined whether blocki...

The purpose of this study is to survey cross section changes of the animal brain samples during the tension and compression tests and comparison of the experimental results for three animals: bovine, sheep, and rabbit. A linear elastic theory with considering the necking in tension and barreling in compression has been considered for brain tissue. Bridgman method for tension and cross section u...

Traumatic brain injury is usually assessed with the Glasgow coma scale (GCS), CT, or MRI. After such injury, the injured brain tissue is characterised by calcium mediated neuronal damage and inflammation. Positron emission tomography with the isotope cobalt-55 (Co-PET) as a calcium tracer enables imaging of affected tissue in traumatic brain injury. The aim was to determine whether additional i...

in order to evaluate the effect of different concentrations of postharvest salicylic acid and calcium chloride on shelf life, quality characteristics and antioxidant activity of peach fruit cv. amesden, an experiment was conducted as factorial based on randomized completely design with three replications. fruits were harvested at the commercial ripening stage, and fruits were immerged in differ...