Explicit stabilized methods for stiff ordinary differential equations have a long history. Proposed in the early 1960s and developed during 40 years for the integration of stiff ordinary differential equations, these methods have recently been extended to implicit-explicit or partitioned type methods for advection-diffusion-reaction problems, and to efficient explicit solvers for stiff mean-squ...

Contributors Publication dates Originally released September 2, 1994; last updated June 7, 2010; expires June 7, 2013 Synonyms Stiff-man syndrome Key points • Stiff-person syndrome is a rare disorder that causes continuous muscle contraction with spasm, abnormal postures, and progressive disability. • Stiff-person syndrome is often associated with other autoimmune signs and symptoms as well as ...

This paper introduces two new numerical methods for integration of stiff ordinary differential equations. Following the idea of quantization based integration, i.e., replacing the time discretization by state quantization, the new methods perform first and second order backward approximations allowing to simulate stiff systems. It is shown that the new algorithms satisfy the same theoretical pr...

a very stiff and a very weak, light support were used. Close correlation was obtained between body displacement and light support displacement; body motion greatly exceeded that of the stiff support. Single mass resonant frequency was set by the dorsal skin stiffness when the support was very stiff and by the support stiffness when the light support was used. With both supports the body exhibit...

INTRODUCTION First described in 1956, stiff person syndrome is characterized by episodes of slowly progressive stiffness and rigidity in both the paraspinal and limb muscles. Although considered a rare disorder, stiff person syndrome is likely to be under-diagnosed due to a general lack of awareness of the disease in the medical community. CASE PRESENTATION A 27-year-old Hispanic woman presen...

Stiff-person syndrome or Moersch-Woltmann is a very rare and disabling neurologic disorder characterized by muscle rigidity and episodic spasms involving axial and limb musculature. It is an autoimmune disorder resulting in a malfunction of aminobutyric acid mediated inhibitory networks in the central nervous system. We describe a patient of stiff person syndrome.

Four patients had a chronic progressive disorder beginning in middle age and involving stiffness and painful spasms of the lower limbs. Spasms were spontaneous, reflex, and induced by voluntary movement. Patients had rigidity and abnormal postures of one or both legs. There was no truncal rigidity or exaggerated lumbar lordosis. Despite the presence of symptoms for up to 16 years, symptoms and ...

A female patient had permanent axial muscular rigidity similar to the "stiff-man syndrome", together with axial myoclonus triggered by stretch reflexes and by supramaximal stimulation of the supraorbital nerve. The disorder responded to treatment with diazepam and baclofen. This disorder bore a marked similarity to the so-called "jerking stiff-man syndrome".