BACKGROUND Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in children. CASE PRESENTATION A 57-year-old Caucasian man was admitted to the emergency room in a feb...

Although the drug topiramate initially was developed for the treatment of epilepsy and received its first US Food and Drug Administration (FDA) approval for that purpose, it subsequently was shown to be effective for the prevention of migraine headaches and is FDA approved for that indication as well. Migraine and epilepsy share a considerable number of biologic and clinical features, and it fo...

CASE REPORT We describe a 42 year-old patient who developed acute myopia and closed-angle glaucoma one week after beginning treatment with topiramate. Ultrasound biomicroscopy revealed a bilateral angle closure and choroidal effusion. The clinical findings resolved with withdrawal of the topiramate. DISCUSSION Topiramate may cause acute myopia and closure angle glaucoma in some patients due t...

Heat stroke is the most severe pathology related to heat. It is defined as an increase in core body temperature accompanied by signs of neurological dysfunction. In the absence of an early treatment, it has a very high mortality rate. Topiramate is a well known drug widely used in epilepsy treatment and migraine prevention. Oligohydrosis has been described amongst topiramate side effects, favou...

in published high performance liquid chromatographic (hplc) methods for analysis of topiramate (tpm) in pharmaceutical dosage forms and raw materials refractive index detector (rid) has been used which is not available in many laboratories and has low sensitivity. we described a new, sensitive and simple hplc method for determination of topiramate in pharmaceutical forms and in-virto dissolutio...

A 27-year-old man with a diagnosis of new onset refractory status epilepticus (NORSE) was treated with five anti-seizure drugs (ASDs) including clobazam, levetiracetam and topiramate. He received plasma exchange (PE) for presumed autoimmune etiology. Serum ASD levels were serially monitored in two sessions. Levels of clobazam, levetiracetam and topiramate were significant reduced by PE. Serum c...

CASE HISTORY A 43-year-old woman has a 20-year history of migraine without aura. Two years ago, she was having about 8 migraines per month lasting 1–2 days with a variable response to triptans. She was placed on topiramate, 100 mg daily. Since then, there has had a dramatic reduction in the number of headaches to about once or twice monthly. She is typically pain free within 1 or 2 hours upon t...

INTRODUCTION Weight-management options include lifestyle modifications, bariatric surgery and, until recently, limited pharmacotherapy. Phentermine and topiramate extended-release (phentermine/topiramate ER) has recently been approved in the USA for chronic weight management in obese adults and overweight adults with weight-related co-morbidities in conjunction with a reduced-calorie diet and i...

Abstract: Background: Because neuropathic pain is currently a poorly understood medical condition, there need to identify more effective therapeutic drug with low toxicity profile. Purpose: To address the behavioural, oxidative stress, and cytokine-mediated inflammatory pathways involved in sciatic nerve, current study protocol used Chronic Constriction Injury (CCI) Streptozotocin (STZ) induced...

how to cite this article: ashrafi mr, najafi z, shafiei m, heidari k, togha m. cinnarizinev ersus topiramate in prophylaxis of migraines among children and adolescents: a randomized, double-blind clinical trial. iran j child neurol. 2014 autumn;8(4): 18-27.   abstract objective migraines, a common health problem in children and adolescents, still do not have an fda approved preventive treatment...