ulcerative colitis is a mucosal-inflammatory disease that usually involves the rectum and extends proximally to involve all or part of the colon. medications for treatment include anti-inflammatory agents such as 5-asa compounds, systemic and topical corticosteroids and immunomodulators. a 33 year-old female and 52 year-old male both diagnosed with severe active ulcerative colitis who were resi...

dentin hypersensitivity (dh) is a relatively common painful condition among dental problems. although many studies have been performed regarding the diagnosis and treatment of dh, dental practitioners are still confused about the definite diagnosis and treatment.the use of lasers as a treatment for dentin hypersensitivity was first introduced in 1985. laser treatment in dentin hypersensitivity ...

Chronic actinic dermatitis is a chronic photosensitivity disorder characterized by severe eczematous lesions on sun-exposed skin areas. We report a case of chronic actinic dermatitis presenting with leonine facies and secondary adrenal insufficiency, which was successfully treated with topical tacrolimus. The facial lesions dramatically improved after sun avoidance and topical tacrolimus applic...

Background: Topical corticosteroids and oral psoralen plus ultraviolet A radiation (PUVA therapy) are two common treatment methods for vitiligo. The aim of this study was to compare the efficacy, complications and patterns of repigmentation of these two methods. Methods: This prospective randomized clinical trial was conducted from July 2007 to October 2008. Patients with disseminated vitiligo ...

PURPOSE To evaluate the role of prepared basic fibroblast growth factor (bFGF) and cytochrome c peroxidase (CCP) combination eyedrops in corneal epithelial healing of transgenic mice (B6(A)-Rpe(rd12)/J) after excimer laser photoablation. MATERIALS AND METHODS In this prospective study, 216 eyes of 108 mice underwent bilateral photorefractive keratectomy. We considered 4 groups: A, B, C, and D...

With selected patients glaucoma filtration surgery is highly successful. However, there is growing evidence that chronic topical medical therapy has a deleterious effect on surgical outcome. It has been suspected that topical drugs exert an adverse effect on the conjunctiva which results in altered postoperative wound healing. In this review the effect of previous topical antiglaucoma medicatio...

Due to years of sophisticated research on T cell function, many dermatologists have viewed atopic dermatitis (AD) largely as an inflammatory disorder of TH1/TH2 imbalance. Hence, therapy has largely consisted of topical immunomodulators and/or steroids. The imposition of "black box" warnings about the potential toxicity associated with prolonged use of the immunosuppressive drugs, tacrolimus 0....

Background. Lichen sclerosus (LS) is an autoimmune inflammatory skin disease that leads to tissue sclerosis. Actually, the first-line treatment consists of local steroid as clobetasol propionate (CP). Polydeoxyribonucleotide (PDRN) has demonstrated anti-inflammatory effects through the reduction of cytokine production and growth stimulation of fibroblast. Objective. To evaluate the efficacy of ...

We report a 69-year-old female with erythroblastopenia and thymoma who developed lesions of Kaposi's sarcoma (KS) after thymectomy, 2 months after the initiation of therapy with methylprednisolone. Control of mucocutaneous KS lesions was obtained with radiotherapy, interferon alfa-2b and withdrawal of systemic immunosuppressive therapy. Erosive oral lichen planus appeared later, and after thera...

Regulatory approval of topical nadifloxacin for the treatment of acne vulgaris was based on data from controlled and randomised clinical trials using a monotherapy regimen. Frequently in dermatological practice, however, multi-regimen approaches are used. This prospective trial was conducted to assess clinical use and value of topical nadifloxacin in the treatment of acne vulgaris under routine...