A novel nanocrystal system of montelukast (MTK) was designed to improve the transdermal delivery, while ensuring chemical stability labile compound. MTK Nanogel fabricated using nano dispersion method (Modified emulsification diffusion method). In pre-formulation study, there not any physicochemical interaction between drug and polymer had been evaluated by FTIR. The melting point found be 134-...

Tacrolimus (TAC) suspension is used to treat moderate severe atopic keratoconjunctivitis (AKC) and vernal (VKC). The objectives of this study were formulate the hydrophobic compound TAC in an aqueous eye drop formulation its ocular biodistribution on topical application a healthy rabbit model, with overall aim using AKC VKC. A thin-film hydration method was encapsulate within chitosan-based amp...

BACKGROUND Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested. OBJECTIVE Novel vehicles for topical glucocorticoids formulation were evaluated for the efficacy of reducing side-effects and the drug delivery prop...

The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulat...

When liposomes were initially discovered more than 30 years ago, predictions were largely met with skepticism; however, recent advances have allowed the development of liposomes that are potentially medically useful. Systemic and topical drug delivery by liposomes is possible. Although liposomal amphotericin B, a systemic antifungal agent, is the only medical liposomal product commercially avai...

The development of topical anesthetics has provided the family physician with multiple options in anesthetizing open and intact skin. The combination of tetracaine, adrenaline (epinephrine), and cocaine, better known as TAC, was the first topical agent available for analgesia of lacerations to the face and scalp. Cocaine has been replaced with lidocaine in a newer formulation called LET (lidoca...