Introduction Squamous cell carcinoma (SCC) is the most common type of malignancy head and neck region arising from mucosal epithelium oral cavity oropharynx. It a multifactorial disease with high rate mortality. Lymph node metastasis an important prognostic parameter associated adverse prognosis. This study was conducted to establish relationship between various clinicopathological characterist...

OBJECTIVES Squamous cell carcinoma (SCC) is the most common oral malignancy, and verrucous carcinoma (VC) is a less invasive type of SCC. Leukoplakia (LP) is the most frequent premalignant lesion in the oral cavity. The human papillomavirus (HPV) has been recognized as one of the etiologic factors of these conditions. The association of anogenital and cervical cancers with HPV particularly its ...

Methods: Retrospective analysis of 48 patients diagnosed with SCC of the tongue, between 2005-2012. All patients had a T1-2, N0 disease, and were treated with complete resection of the tumor and elective neck dissection. The following were defined as minor adverse features (MAF): perineural invasion, perivascular invasion, close margins <5mm, depth of invasion (DOI) >5mm, and poor differentiati...

Metastatic SCC of the neck is frequently seen, however occasionally the primary site is not identified. Gone are the days of the ‘blanket biopsy’ of tonsil, tongue base, larynx, bronchus and oesophagus. Although PET can aid in pinpointing the primary tumour location, there still exist a number of patients with a true ‘unknown primary’. Part of any cancer service is follow-up, after treatment, t...

BACKGROUND The incidence of oral cancers varies from one country to another, which can be clarified by the difference in the distribution of the risk factors and the possible etiologies. Tongue is a main segment of oral cavity and malignant lesions of this region accounts for nearly 30% of all oral cancers. OBJECTIVES In the present study, we evaluated the pattern of tongue cancer in Iranian ...

The multifunctional G-protein-coupled metabotropic glutamate receptor (mGluR) family comprises eight subtypes, some of which participate in tumorigenesis. The purpose of this study was to evaluate mGluR5 expression in oral squamous cell carcinoma (SCC) tissues and oral cancer cell lines. We also investigated the prognostic significance of mGluR5 and its functional importance in the migration, i...

Curative treatment for base-of-tongue squamous cell carcinoma (BOT SCC) has evolved over time; however, comparative outcomes analysis for various treatment strategies is lacking. The authors reviewed the evolution of treatment modality and radiotherapy (RT) technique for 231 consecutive BOT SCC patients at our institution between 1981 and 2011. Treatment modalities included definitive chemoradi...

BACKGROUND In squamous cell carcinoma (SCC) of the tongue and the floor of the mouth (FOM), it is important to predict lymph node metastasis, including occult metastasis, before operating. The purpose of this study was for us to determine practical histopathologic parameters as predictive factors for lymph node metastasis in preoperative SCC biopsy specimens. METHODS We examined 91 cases of S...

Keratoacanthoma (KA) is a benign epithelial tumor characterized by an infiltrating nature, multiple or localized occurrence, and a self-healing course. It commonly occurs on the exposed skin, especially in the head and neck region, and very rarely on the mucosal membrane of the oral cavity. From our review of the English-language literature, this report appears to be the first documented case o...

The crosstalk between immune cells, cancer cells, and extracellular vesicles (EVs) secreted by cancer cells remains poorly understood. We created three-dimensional (3D) cell culture models using human leiomyoma discs and Myogel to study the effects of immune cells on highly (HSC-3) and less (SCC-25) invasive oral tongue squamous cell carcinoma (OTSCC) cell lines. Additionally, we studied the ef...