Despite intense research, squamous cell carcinoma of the tongue remains a devastating disease with a five-year survival of around 60%. Late detection and recurrence are the main causes for poor survival. The identification of circulating factors for early diagnosis and/or prognosis of cancer is a rapidly evolving field of interest, with the hope of finding stable and reliable markers of clinica...

Global miRNA expression arrays were used for analysis of 836 miRNAs in formalin-fixed paraffin-embedded samples from 21 tongue cancer patients and 8 controls. Samples had been stored for one to eleven years. Results separated tumour samples from controls, however, the largest variation was correlated to sample storage time, detectable already after one year. With the use of a linear regression ...

BACKGROUND AND OBJECTIVE Secreted protein acidic and rich in cysteine (SPARC) is expressed widely in malignant tumors. It is related to prognosis and biological behaviors of tumors. This study was to detect the expression of SPARC in stage II tongue squamous cell carcinoma and analyze its relationship with prognosis. METHODS Tongue carcinoma samples (T2N0M0) were obtained from 55 patients tre...

Imaging and quantification of tongue anatomy is helpful in surgical planning, post-operative rehabilitation of tongue cancer patients, and studying of how humans adapt and learn new strategies for breathing, swallowing and speaking to compensate for changes in function caused by disease, medical interventions or aging. In vivo acquisition of high-resolution three-dimensional (3D) magnetic reson...

The aim of the present study was to identify agents capable of inhibiting the invasion and metastasis of tongue squamous cell carcinoma and thereby improve the outcomes of patients suffering from tongue cancer. FRMD4A antibodies were used to probe 78 paraffin-embedded specimens of tongue squamous cell carcinoma and 15 normal tongue tissues, which served as controls. Immunohistochemical methods ...

Accumulating data reveal that aldehyde dehydrogenase (ALDH) activity is a cancer stem cell marker in several types of human cancers. Whether ALDH also defines cancer stem cells of tongue squamous cell carcinoma is unknown. In the present study, we performed the Aldefluor assay to detect ALDH enzymatic activity, and used flow cytometry to isolate ALDH+ and ALDH- cells based on their ALDH activit...

Previous studies show that a number of natural compounds from our diet have anticancer effects. Sulforaphane is the most characterized isothiocyanates (ITCs), which are identified in cruciferous vegetables. Sulforaphane is viewed as a conceptually promising agent in cancer prevention. Because of its ability to induce cancer cell apoptosis, it inhibits progression of benign tumors to malignant t...

Head and neck cancer is a disease arising in various organs, including oral cavity, tongue, pharynx, and larynx. Oral tongue squamous cell carcinoma (OSCC) is the most common form of head and neck cancer and is the major cause of death among all forms of head and neck cancer globally (Lippman et al., 2005; Parkin et al., 2005; Sudbo and Reith, 2005). In this study, we focused on OSCC, which is ...