A piperidinyl chlorotriazine (PCT) derivative, used as a plastic UV-stabilizer, caused an outbreak of occupational asthma. We verified, in BALB/c mice, the sensitizing potential of PCT in comparison to a known respiratory sensitizer (toluene diisocyanate [TDI]) and a known dermal sensitizer (oxazolone), using three different methods in order to evaluate the validity of current models of sensiti...

BACKGROUND Diastolic dysfunction is common in early hypertension. We hypothesized that improvement in diastolic dysfunction is blood pressure (BP) dependent and may occur early with treatment in newly diagnosed untreated hypertensive patients. METHODS Forty untreated hypertensive subjects (age 52 +/- 1.4 years, mean +/- s.e.m.) with diastolic dysfunction based on Canadian Consensus Guidelines...

Several studies on the prognosis of occupational asthma have shown that a significant proportion of patients continue to experience asthmatic symptoms and nonspecific bronchial hyperresponsiveness after cessation of work. The determinants of this unfavourable prognosis of asthma are: long duration of exposure before the onset of asthma; long duration of symptoms before diagnosis; baseline airwa...

The successful application of X-ray spectromicroscopy to chemical analysis of polymers is reviewed and a detailed application to quantitative analysis of polyurethanes is presented. Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy is the basis of chemical sensitive X-ray imaging, as well as qualitative and quantitative micro-spectroscopy. These capabilities are demonstrated by a ...

AIMS To assess whether cancer incidence and mortality in chronic obstructive lung diseases were increased in the Swedish polyurethane foam industry cohort, updated with 11 more years of follow up. METHODS The mortality and cancer incidence (1959-98) experienced by a cohort of 4175 male and female employees employed for at least one year in the period 1959-87 at one of nine Swedish polyurethan...

Occupational asthma HLA locus Antigen presentation Genetics Corresponsence to: Dr. L. M. Fabbri, Laboratorio di Fisiopatologia Sperimentale, Università di Ferrara, Via Luigi Borsari 46, l–44100 Ferrara (Italy) Exposure to toluene diisocyanate (TDI) is associated with a variety of chronic disorders of the lung, including asthma [1]. TDI-induced asthma has been the most common cause of occupation...

Polyfunctional silylureas were synthesized by the interaction of 3-aminopropyltriethoxysilane with isocyanates various structures in an inert aromatic solvent. Commercially available diisocyanates such as isophorone diisocyanate, hexamethylene 2,4-toluene diisocyanate used isocyanates. In this case, freshly distilled toluene was a The obtained compounds confirmed data IR and NMR1H spectroscopy....