نتایج جستجو برای: tobramycin

تعداد نتایج: 2629  

Journal: :Journal of aerosol medicine and pulmonary drug delivery 2016
Ryan A Orizondo Mario L Fabiilli Marissa A Morales Keith E Cook

BACKGROUND The effectiveness of inhaled aerosolized antibiotics is limited by poor ventilation of infected airways. Pulmonary delivery of antibiotics emulsified within liquid perfluorocarbon [antibacterial perfluorocarbon ventilation (APV)] may solve this problem through better airway penetration and improved spatial uniformity. However, little work has been done to explore emulsion formulation...

Journal: :Antimicrobial agents and chemotherapy 1984
G R Matzke C E Halstenson W F Keane

The apparent hemodialyzer elimination rate constant and clearance for gentamicin and tobramycin were determined during 100 routine hemodialysis treatments in 49 patients. Three different dialyzers (CDAK 3500, CF 1211, and CF 1511), which vary in membrane composition, surface area, and thickness, were evaluated. The elimination rate constant in each patient was calculated from the slope of the l...

Journal: :Tropical Journal of Pharmaceutical Research 2023

Purpose: To investigate the effect of an integrated nursing model in day surgeries, treated with tobramycin-dexamethasone suspension, and its influence on patient satisfaction, quality life, indicators immunity recovery.
 Methods: Ninety-eight patients ophthalmic diseases admitted to Anhui No. 2 Provincial People’s Hospital, Anhui, China from January 2021 June 2022 were scheduled for surge...

Journal: :Harran Üniversitesi týp fakültesi dergisi 2021

Objectives: Acinetobacter baumannii causes serious blood stream infections especially in immunocompromised and hospitalized patients. In this study, the distribution of antibacterial resistance among 92 A. isolates 5 lwoffii from cultures collected at Harran University Hospital (Urfa, Turkey) 2017 to 2019 was investigated. Methods: Blood were followed up Versa-TREK (Trek Diagnostic System, USA)...

Journal: :Journal of clinical microbiology 1981
E L Francke S Srinivasan P Labthavikul H C Neu

An enzyme immunoassay for tobramycin utilizing glucose 6-phosphate dehydrogenase was compared with the radioimmunoassay. The enzyme immunoassay for tobramycin was accurate, specific, and easily performed. It offers an alternative method for assaying aminoglycosides and could be used in institutions that use the enzyme immunoassay to assay other drugs.

Journal: :British medical journal 1977
P Wilson R T Ramsden

Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.

Journal: :Journal of clinical microbiology 1984
P Huovinen P Grönroos E Herva M L Katila M L Klossner O V Renkonen P Toivanen

A total of 633 blood culture isolates were collected from 1981 to 1982 from seven major Finnish hospitals, including all university central hospitals. Susceptibility of the strains to gentamicin, tobramycin, amikacin, and netilmicin was determined by the Sensititre microtiter procedure. Resistance against any of these agents occurred in 1.3 to 6.5% of all strains studied. In the Turku Universit...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2007
Osama Hussein Kamel Mohamed Ihab M Wahba Suzanne Watnick Sandra B Earle William M Bennett James W Ayres Myrna Y Munar

BACKGROUND Aminoglycoside antibiotic efficacy is related to peak concentration (C(max)) and postantibiotic effect, whereas toxicity is directly related to body exposure as measured by area under the serum concentration versus time curve (AUC). On the basis of pharmacokinetic simulation models, tobramycin administration during the first 30 min of high-flux hemodialysis achieves similar C(max) bu...

Journal: :Antimicrobial agents and chemotherapy 1972
J A Waitz E L Moss C G Drube M J Weinstein

Gentamicin, sisomicin, tobramycin, and kanamycin were compared in parallel tests in vitro and in vivo against a variety of bacterial strains and species. A number of differences were seen in vitro, in particular: (i) the lower activity of kanamycin, (ii) the greater activity of tobramycin against Pseudomonas, (iii) the greater activity of gentamicin and sisomicin against Serratia, and (iv) the ...

Journal: :The Journal of antimicrobial chemotherapy 2012
Qianru Yu Edward F Griffin Sophie Moreau-Marquis Joseph D Schwartzman Bruce A Stanton George A O'Toole

OBJECTIVES Aztreonam for inhalation solution (AZLI) was recently approved by the FDA for treating cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Here we investigated the effect of aztreonam alone or in combination with tobramycin on P. aeruginosa biofilms grown on CF airway epithelial cells. METHODS P. aeruginosa biofilms, produced by laboratory strains or clinical isolat...

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