نتایج جستجو برای: tnp

تعداد نتایج: 816  

Journal: :Journal of immunology 2001
J Stöckl O Majdic G Fischer D Maurer W Knapp

Hapten-specific T cells have been shown to recognize haptenated peptides with high avidity and, in some instances, with promiscuous MHC restriction. In this study, the impact of Ag density on MHC restriction of a CTL response specific to the trinitrophenyl (TNP) hapten was investigated. In this study, we demonstrate a novel recognition mechanism used by TNP-specific CD8(+) CTL in the presence o...

Journal: :Nature communications 2015
Miles A Miller Yao-Rong Zheng Suresh Gadde Christina Pfirschke Harshal Zope Camilla Engblom Rainer H Kohler Yoshiko Iwamoto Katherine S Yang Bjorn Askevold Nagesh Kolishetti Mikael Pittet Stephen J Lippard Omid C Farokhzad Ralph Weissleder

Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their heterogeneous behaviour. Model TNPs comprising a fluorescent platinum(IV) pro-drug and a clinically t...

Journal: :The Journal of Experimental Medicine 1979
C Bona W E Paul

An idiotype of the dinitrophenyl-binding myeloma protein MOPC 460 was expressed on a small but significant proportion of anti-TNP antibodies which appeared after in vivo or in vitro immunization of BALB/c mice with three T-independent TNP antigens. In vitro experiments show that the depletion of T cells before culture increased significantly the number of plaques secreting anti-TNP antibodies b...

2001
Jianguo Ma Sharon Pulfer Shaolan Li Jianxiong Chu Karin Reed James M. Gallo

The angiogenic phenotype is associated with increased tumor neovascularization and a state of vascular hyperpermeability to macromolecules. Angiogenesis inhibitors could reverse these processes, resulting in tumor capillaries that have normal membrane permeability. It was proposed that the switch from a hyperpermeable to a normal permeable state could have the untoward effect of decreasing tumo...

Journal: :Lymphology 2003
S Seki A Fujimura

We examined the three-dimensional changes of the lymphatic architecture in the rabbit VX2 tongue cancer model after administration of an antiangiogenic agent, TNP-470. TNP-470 at 30 mg/kg was administered via the auricular vein to the rabbit four times every other day from 3 days after transplantation of the tumor. The tongue and both sides of deep cervical lymph nodes of rabbit were observed a...

Journal: :Journal of immunological methods 1991
T Shimada H Yoshida H Tokumoto J Yodoi T Sugiyama

To establish a sensitive method to detect IgA Fc receptors (Fc alpha R) on human and murine lymphoid cells, fluorescent microspheres (FMS) were used in a flow cytometric assay. The following three assays with FMS were tested and compared with a conventional indirect Fc alpha R assay using FITC-labeled anti-IgA: (1) direct cell binding assay with murine myeloma IgA(MOPC315)-coated FMS(IgA-FMS as...

Journal: :Annali italiani di chirurgia 2013
Ciro De Martino Paolo Caiazzo Michele Albano Francesco Calbi Mauro Pastore Pio Rocco Tramutoli

INTRODUCTION The aim of this study was to assess the authors' initial experience with laparostomy and intraperitoneal topical negative pressure (TNP) in patients with severe peritonitis. The authors also reviewed the recent literature on the effectiveness and safety of abdominal TNP. PATIENTS AND METHODS Sixteen patients (10 male, 6 female, mean age 55 years), suffering from severe peritoniti...

Journal: :Antimicrobial agents and chemotherapy 1997
E S Didier

Presently, the two most commonly used drugs for treating microsporidiosis in persons with AIDS are albendazole and fumagillin. Albendazole is effective for treating disseminated infections due to Encephalitozoon spp. but is variably effective against Enterocytozoon bieneusi infections. Fumagillin is highly effective when used topically to treat ocular infections with Encephalitozoon hellem or E...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
S Shusterman S A Grupp R Barr D Carpentieri H Zhao J M Maris

Tumor vascularity is highly correlated with disease outcome in neuroblastoma. Thus, novel therapeutics that target the vascular endothelium are candidates for incorporation into clinical trials. We therefore examined the effect of TNP-470 on human neuroblastoma growth in mouse models reflecting both clinically evident and minimal disease. Mice were inoculated s.c. or by tail vein injection with...

2003
LINDA M. HILLSTROM JOHN E. NIEDERHUBER

Regulation of the immune response by genes located in the major histocompatibility complex (MHC) a has been extensively investigated (1-5). As a result of these studies, it has been concluded that the Ir genes of the M H C code for cell surface structures termed Ia antigens. Recognition of appropriate Ia determinants on antigen-presenting cells by Ly-1 + T cells is required for successful induc...

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