Objective: This study aimed to examine the incidence, clinical characteristics, and outcome of hyperuricemia and tumor lysis syndrome (TLS) in children with non-Hodgkin’s lymphoma (NHL) and acute lymphoblastic leukemia (ALL). Materials and Methods: This retrospective study included data from 327 patients (113 NHL and 214 ALL). Results: Hyperuricemia occurred in 26.5% and 12.6% of the patients w...

Tumor lysis syndrome (TLS) is a potentially life-threatening condition that occurs in oncologic and hematologic patients with large tumor burden, either due to cytotoxic therapy or, less commonly, spontaneously because of massive tumor cell lysis. TLS is clinically characterized by acute renal failure, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. While limited options are a...

Neuronal dendrites, together with dendritic spines, exhibit enormously diverse structure. Selective targeting and local translation of mRNAs in dendritic spines have been implicated in synapse remodeling or synaptic plasticity. The mechanism of mRNA transport to the postsynaptic site is a fundamental question in local dendritic translation. TLS (translocated in liposarcoma), previously identifi...

BACKGROUND Tumor lysis syndrome (TLS) is a potentially fatal complication in patients with large, rapidly proliferating tumor cell cancers that may occur after chemotherapy. Patients with TLS are complicated to treat and often have an unpredictable trajectory. OBJECTIVES The purpose of this article is to report two cases with unusual clinical manifestations and unexpected outcomes during canc...

Development of tumor lysis syndrome (TLS) may occur after chemotherapy or spontaneously in bulky or rapidly growing tumors. This syndrome is frequent but preventable in patients with hematologic malignancies. TLS following therapy has been reported infrequently in various types of solid tumors. TLS associated with oxaliplatin containing chemotherapy in a solid tumor has never been reported. A 5...

The Internet today is a highly dynamic environment which frequently requires secure communication between peers that do not have a direct trust relationship. Current solutions for establishing trust often require static and application-specific Public Key Infrastructures (PKIs). This paper presents trusted directory services as a key infrastructural technology for setting up secure Internet con...

Tumor lysis syndrome (TLS) is an oncology emergency that occurs as a result of rapid tumor cell breakdown and the consequent release of massive amounts of intracellular contents, including potassium, phosphate, and uric acid, into the systemic circulation. These metabolic disturbances lead to life-threatening conditions and may cause sudden death if not treated. TLS commonly occurs following in...

We present FLEXTLS, a tool for rapidly prototyping and testing implementations of the Transport Layer Security (TLS) protocol. FLEXTLS is built upon MITLS, a verified implementation of TLS, and hence protocol scenarios written in FLEXTLS can benefit from robust libraries for messaging and cryptography. Conversely, attack scripts in FLEXTLS can be used to evaluate and communicate the impact of n...

UNLABELLED Translocated in liposarcoma (TLS) is a poorly characterized multifunctional protein involved in the genotoxic response. TLS regulates gene expression at several steps, including splicing and mRNA transport, possibly connecting transcriptional and posttranscriptional events. AIMS In this study we aimed to idenfity molecular targets and regulatory partners of TLS. RESULTS AND INNOV...

In this paper, we account for approaches of sparse recovery from large underdetermined linear models with perturbation present in both the measurements and the dictionary matrix. Existing methods have high computation and low efficiency. The total least-squares (TLS) criterion has welldocumented merits in solving linear regression problems while FOCal Underdetermined System Solver (FOCUSS) has ...