نتایج جستجو برای: tlr4 agonist
تعداد نتایج: 61583 فیلتر نتایج به سال:
Equitable global access to vaccines requires overcoming challenges associated with complex immunization schedules and their economic burdens that hinder delivery in under-resourced environments. The rabies vaccine, for example, multiple immunizations effective protection each dose is cost prohibitive, therefore inaccessibility disproportionately impacts low- middle-income countries. In this wor...
BACKGROUND The study of the endotoxin tolerance phenomenon in light of the recently defined roles of mast cells and toll-like receptors as essential components of the innate immune response and as orchestrators of acquired immunity may reveal potentially useful mechanisms of immunomodulation of infectious and allergic inflammatory responses, such as sepsis or asthma. Here we evaluated the pheno...
Reactivation of antigen induced arthritis by bacterial lipopolysachharide (LPS) in a murine model was used to determine whether Terminalia chebula exerts its protective activity via modulation of Toll-like receptors (TLR). Arthritis was induced in 8-9 weeks old female Swiss albino mice by intra-articular antigen challenge following immunization with antigen. Oral administration of LPS caused re...
Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway
The calcineurin B subunit (CnB) is the regulatory subunit of Cn, a Ca(2+)/calmodulin-dependent serine/threonine protein phosphatase. In this study, we demonstrate that extracellular CnB was effectively internalized through a CD14-independent Toll-like receptor 4 (TLR4) pathway, which led to the phosphorylation of nuclear factor (NF)-kappa-B inhibitor alpha (IκB-α) and upregulation of pro-inflam...
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