OBJECTIVE This was an evaluation of the cost-effectiveness of oral dabigatran etexilate compared with subcutaneous low-molecular-weight heparin (enoxaparin) for the prevention of venous thromboembolism (VTE) after total knee replacement (TKR) and total hip replacement (THR) surgery from the perspective of the UK National Health Service. METHODS Dabigatran etexilate (220 mg once daily) was com...

THE JOURNAL OF BONE AND JOINT SURGERY and of creep encountered in TKR designs are the direct result of failing to allow adequately in the design for the properties of the materials. Thus, no modification of material or new composition will necessarily improve the performance of the total joint replacement. The acquisition of improved materials with wellcharacterised mechanical and biological pe...

PURPOSE To assess the consent process for elective primary total hip replacement (THR) and total knee replacement (TKR) in our hospital. METHODS Consent processes of 47 THR and 53 TKR patients performed by 11 surgeons were reviewed. Complications that were documented were recorded, as was the grade of surgeon (consultant or specialist trainee) performing consent, and the location at which thi...

INTRODUCTION Stable long-term fixation in cementless total knee replacement (TKR) depends on the development and maintenance of adequate trabecular bone around the prosthesis. Since bone mineral density (BMD) values are predictive of the mechanical properties of bone, the measurement of BMD has emerged as an important and potentially valuable means of assessing the effects of total joint replac...

Total knee replacement (TKR) comprises a significant, growing aspect in the management of patients with advanced arthritis of the knee for which conservative medical therapy has failed. Obesity, a rising epidemic, is considered an important independent risk factor in the development of osteoarthritis (OA). An aging population and increasing incidence of obesity contribute to a higher prevalence...

We wished to determine whether simultaneous bilateral sequential total knee replacement (TKR) carried increased rates of mortality and complications compared with unilateral TKR in low- and high-risk patients. Our study included 2385 patients who had undergone bilateral sequential TKR under one anaesthetic and 719 who had unilateral TKR. There were no significant pre-operative differences betwe...

OBJECTIVES There are few Australian data that examine the association between total knee joint replacement (TKR) utilisation and socioeconomic status (SES). This study examined TKR surgeries with a diagnosis of osteoarthritis (OA) performed for residents of Barwon Statistical Division (BSD) for 2006-2007. DESIGN Cross-sectional. SETTING BSD, South-eastern Victoria, Australia PARTICIPANTS ...

We conducted a retrospective study to investigate the effect of femoral bowing on the placement of components in total knee replacement (TKR), with regard to its effect on reestablishing the correct mechanical axis, as we hypothesised that computer-assisted total knee replacement (CAS-TKR) would produce more accurate alignment than conventional TKR. Between January 2006 and December 2009, 212 p...

OBJECTIVE Prevalence of total knee replacement (TKR) is large and growing but functional outcomes are variable. Physical therapy (PT) is integral to functional recovery following TKR but little is known about the quantity or content of PT delivered. Purposes of this study were to describe the amount and exercise content of PT provided in the terminal episode of PT care following TKR and to exam...

Population pharmacokinetic (PK) and exposure-response analyses of apixaban were performed using data from phase I-III studies to predict bleeding risks for patients receiving apixaban 2.5 mg b.i.d. after total knee or hip replacement (TKR, THR) surgery (N = 5,510). Renal function, age, gender, and body weight impacted apixaban exposure. Bleeding risk increased as a function of exposure. Predict...