Metabolism of carbon tetrachloride is essential for its toxic effect on intracellular components of the hepatocytes (Butler, 1961 ; Recknagel, 1967). Carbon tetrachloride decreases the biliary excretion of foreign organic compounds of high molecular weight (Barakat & Abou-El-Markarem, 1973). Whether metabolism of carbon tetrachloride is also essential for this effect, will be discussed here. Va...

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

Nano-sized titanium dioxide TiO2 powder was successfully prepared from its precursor titanium (IV) chloride by a simple and new wet chemical method. TiCl4 were used as precursor in hydrogen peroxide, H2O2 and ethanol. This solution was then peptized using nitric acid and heated under reflux at 80°C. Their physico-chemical properties were then characterized by transmission electron microscopy (T...

In this work, the compound 2 named ethyl (1,1-dichloro-1a,5,5,7-tetramethyl-8-oxo-1a,2,3,4,5,5a,8,9-octahydro-1H-benzo[a]cyclopropa[b][7]annulen-6-yl)glycinate (C20H29Cl2NO3) was synthesized from ?,?-unsaturated sesquiterpene ketone 1 using azido-Schmidt reaction catalyzed by titanium tetrachloride (TiCl4). The structure of newly enaminone fully identified its HRMS, FT-IR, UV-Visible, NMR (1H &...

Rat liver microsomal membranes contain a reduced-glutathione-dependent protein(s) that inhibits lipid peroxidation in the ascorbate/iron microsomal lipid peroxidation system. It appears to exert its protective effect by scavenging free radicals. The present work was carried out to assess the effect of this reduced-glutathione-dependent mechanism on carbon tetrachloride-induced microsomal injury...