Purpose: To optimize and formulate promethazine theoclate fast-dissolving tablets that offer a suitable approach to the treatment of nausea and vomiting. Method: The solubility of promethazine theoclate was increased by formulating it as a fast-dissolving tablet containing β-cyclodextrin, crospovidone, and camphor, using direct compression method. A 3 3 full factorial design was used to investi...

objective: application of chemical solvents especially in problematic canals is usually a part of the retreatment process.this study was performed to compare the solubility of gutta- percha and resilon in chloroform and to find the effect of sample thickness as well as the time of shaking on their solubility. materials and methods: specific weight of resilon and gutta-percha was placed in a sam...

The hydrochloride of Sertraline is a white crystalline powder; slightly soluble in water and freely soluble in ethanol [1]. It is a drug of selective serotonin reuptake inhibitors (SSRI) that is chemically unrelated to other SSRIs, tricyclic, tetracyclic, or other available antidepressant drugs. Sertraline inhibit the inactivation of serotonin (5hydroxytryptamine or 5-HT) by blocking its absorp...

A numerical model based on the convective-diffusive transport of reacting and adsorbing proteolytic enzymes within erodible fibrous biopolymers was used to predict lysis fronts moving across biogels such as fibrin or collagen. The fiber structure and the transport properties of solutes in fibrin (or collagen) were related to the local extent of dissolution within the dissolving structure. An ac...

Calcium oxalate crystals are responsible for formation of urinary calculi. Traditional therapy based on plants and herbal resources have found beneficial treatment kidney stones. The present study aimed to screen antilithiatic antioxidant potential Polyalthia Longifolia leaves methanolic extract. extract was evaluated the presence secondary metabolites, total phenolic content flavonoid contents...

It iswell-established that the transdermal route is an attractive alternative for minimally-invasive drug delivery. The potential of the skin as a site for vaccine delivery has been demonstrated over the past decade, with research indicating stronger immune responses and improved duration of immunity compared with conventional intramuscular administration. Benefits of this minimally invasive va...

The neutral organic dye indigo forms an inorganic-organic hybrid material with nanoclays (see picture; blue circles on disks symbolizing indigo, spheres indicating liberated cations) and can thus be transferred into aqueous solution. Solids recovered from these solutions resemble the ancient Maya Blue pigment. The method can also be applied to other hydrophobic species and may open the gate for...