BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the remodelling of extracellular matrix (ECM), including basement membrane. ECM remodelling is associated with pathological processes, including hepatic fibrosis, tumor invasion and metastasis. Tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 were known to inhibit MMP-9 and MMP-2, respectively. In the present study, w...

BACKGROUND Cardiac amyloidosis is characterized by amyloid infiltration resulting in extracellular matrix disruption. Amyloid cardiomyopathy due to immunoglobulin light chain protein (AL-CMP) deposition has an accelerated clinical course and a worse prognosis compared with non-light chain cardiac amyloidoses (ie, forms associated with wild-type or mutated transthyretin [TTR]). We therefore test...

OBJECTIVE Matrix metalloproteinases (MMPs), produced by osteoblasts, catalyze the turnover of extracellular matrix (ECM) molecules in osteoid, and the regulation of MMP activity depends on interactions between MMPs and tissue inhibitors of metalloproteinases (TIMPs). We focused on the degradation process of ECM in osteoid that was exposed to mechanical strain, and conducted an in vitro study us...

BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). However, a detailed analysis of MMPs and tissue inhibitors of MMPs (TIMPs) in relation to the biological behavior of HNSCC has yet to be performed in clinical material. OBJECTIVES To study a comprehensive profile of MMPs and their 2 main inhibitors ...

Matrix metalloproteinases (MMPs) are a family of extracellular endoproteinases that are receiving considerable attention from biologists, clinicians, and the pharmaceutical industry. MMPs play a major role in normal development, reproduction, and tissue remodeling. In addition, these molecules are involved in a number of pathogenic processes including cancer, arthritis, angiogenesis, and wound ...

AIM To investigate the relationships among diverse metalloproteases (MMPs) and their tissue inhibitors (TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus (HIV)-infected patients. METHODS Single nucleotide polymorphisms (SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus (HCV) coin...

BACKGROUND Matrix metalloproteinases (MMPs) are involved in remodeling of the extracellular matrix (ECM) during pregnancy and parturition. Aberrant ECM degradation by MMPs or an imbalance between MMPs and their tissue inhibitors (TIMPs) have been implicated in the pathogenesis of preterm labor, however few studies have investigated MMPs or TIMPs in maternal serum. Therefore, the purpose of this...

Submit Manuscript | http://medcraveonline.com Abbreviations: BBB: Blood-Brain Barrier; CCA: Common Carotid Artery; CIMT: Carotid Intima-Media Thickness; COPD: Chronic Obstructive Pulmonary Disease; FEV1: Forced Expiratory Volume in 1 Second; LDL: Low Density Lipoprotein; MMPS: Matrix Metalloproteinases; SCORE Scale: Scale Of Systematic Coronary Risk Evaluation; TIMPs: Tissue Inhibitors of Matri...

Submit Manuscript | http://medcraveonline.com Abbreviations: BBB: Blood-Brain Barrier; CCA: Common Carotid Artery; CIMT: Carotid Intima-Media Thickness; COPD: Chronic Obstructive Pulmonary Disease; FEV1: Forced Expiratory Volume in 1 Second; LDL: Low Density Lipoprotein; MMPS: Matrix Metalloproteinases; SCORE Scale: Scale Of Systematic Coronary Risk Evaluation; TIMPs: Tissue Inhibitors of Matri...

Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncovalently to the pro-form of MMP-2 and inhibits its enzyme activity. In this study, we examined TIMP-...