In 2012, NIST standardized SHA-512/224 and SHA-512/256, two truncated variants of SHA-512, in FIPS 180-4. These two hash functions are faster than SHA-224 and SHA-256 on 64-bit platforms, while maintaining the same hash size and claimed security level. So far, no third-party analysis of SHA-512/224 or SHA-512/256 has been published. In this work, we examine the collision resistance of step-redu...

The nature of the binding site(s) involved in the insulin secretory activity of imidazoline compounds remains unclear. An imidazoline I2 binding site (I2BS) has been neglected since the classic I2 ligand, idazoxan, does not release insulin. Using the rabbit as an appropriate model for the study of this type of binding sites, we have tried to re-evaluate the effects of idazoxan, the selective I2...

The cloning efficiency (CFE-F) of stromal precursor cells (CFU-F) in cultures of heterotopic transplant cells and the quantity of CFU-F in bone marrow transplants from old donors to old recipients (O-O group) has decreased almost eight times, compared with transplants where the bone marrow from young donors has been transplanted to young recipients (Y-Y group). However, in the O-Y group, the CF...

The house dust mites are major sources of indoor allergens for humans, which induce asthma, rhinitis, dermatitis, and other allergic diseases. Der f 25 is a triosephosphate isomerase, representing the major allergen identified in Dermatophagoides farinae. The objective of this study was to predict the B and T cell epitopes of Der f 25. In the present study, we analyzed the physiochemical proper...

Null mutations in Artemis confer a condition described as RS-SCID, in which patients display radiosensitivity combined with severe combined immunodeficiency. Here, we characterize the defect in Artemis in a patient who displayed progressive combined immunodeficiency (CID) and elevated lymphocyte apoptosis. The patient is a compound heterozygote with novel mutations in both alleles, resulting in...

Lipopeptide constructs offer a novel strategy for eliciting effective cellular and humoral immunity by directly targeting the vaccine Ag to dendritic cells. Importantly, it is not known how closely immunity generated after lipopeptide vaccination mimics that generated after natural infection. We have used a novel lipopeptide vaccine strategy to analyze both the quantity and quality of CD8(+) T ...

Much of the current research is being done on social networks, where the cost of an edge is almost nothing; the click of a button in most cases. However, in a graph where each node is an investor and/or investee and each edge is an investment in a company, each edge costs thousands, millions, or potentially billions of dollars. On top of that, each edge is carefully considered, calculated, and ...

Purpose: Copper in serum supports angiogenesis and inhibits replication of wild-type HSV-1. Copper chelation is currently being investigated as an antiangiogenic and antineoplastic agent in patients diagnosed with cancer. Herpes simplex virus–derived oncolytic viruses (oHSV) are being evaluated for safety and efficacy in patients, but several host barriers limit their efficacy. Here, we tested ...