Some drugs currently used to treat tics in pediatric patients have drawbacks, including the risk of side effects. New therapeutic options with better safety profiles are needed. Levetiracetam is an antiepileptic drug with atypical mechanisms of action that might be beneficial for this indication. We evaluated the effects of levetiracetam on motor and vocal tics, behavior, and school performance...

Tumor-initiating stem-like cells (TICs) are resistant to chemotherapy and associated with hepatocellular carcinoma (HCC) caused by HCV and/or alcohol-related chronic liver injury. Using HCV Tg mouse models and patients with HCC, we isolated CD133(+) TICs and identified the pluripotency marker NANOG as a direct target of TLR4, which drives the tumor-initiating activity of TICs. These TLR4/NANOG-...

Cluster analytic methods have examined the symptom presentation of chronic tic disorders (CTDs), with limited agreement across studies. The present study investigated patterns, clinical correlates, and treatment outcome of tic symptoms. 239 youth and adults with CTDs completed a battery of assessments at baseline to determine diagnoses, tic severity, and clinical characteristics. Participants w...

Objective: To report the improvement in symptoms in an adolescent suffering from Tourette’s Syndrome under chiropractic care. Clinical Features: A 14-year old male presented with complaints of motor tics, migraine headaches and severe “fatigue.” The patient was experiencing 1,000 “violent” motor tics a day and was medicated with 6 Ibuprofen pills, 10 mgs of Abilify, and 1mg of ORAP (Pimozide) p...

Este artículo presenta los resultados de una investigación cualitativa sobre la percepción personas internas del centro penitenciario Topas, Salamanca (España) en torno a las oportunidades educativas y el uso TICs que realizan cárcel. Valoran como un hándicap brecha tecnológica falta para compensarla, ya que, su opinión, frenará sus reinserción.
 El derecho al acceso nuevas tecnologías inf...

An 8-year-old girl presented with opsoclonus-like eye movement and an 18 month history of intermittent facial tics. Investigations were all normal. Electro-oculography showed the eye movements to be of variable amplitude (10-40 degrees), with no intersaccadic interval, and with a frequency of 3-4 Hz. Saccades, smooth pursuit, optokinetic, and vestibular reflexes were all normal. These abnormal ...

A tic is a stereotyped repetitive involuntary movement or sound, frequently preceded by premonitory sensations or urges. Most tic disorders are genetic or idiopathic in nature, possibly due to a developmental failure of inhibitory function within frontal-subcortical circuits modulating volitional movements. Currently available oral medications can reduce the severity of tics, but rarely elimina...