We performed a cross-sectional study including 533 individuals (median age 61) from the highly TBE endemic Åland Islands in the archipelago between Sweden and Finland. Blood samples, questionnaires and vaccination records were obtained from all study participants. The aim was to investigate if there was any association between TBEV antibody titer and 12 health-related factors. Measurement of TB...

During 2006-2014, four tick-borne encephalitis (TBE) cases occurred among Israeli travelers. We calculated TBE incidence at 321.0, 45.0, 13.2, and 7.5 cases/100,000 travelers/year of travel to Sweden, Switzerland, Austria, and Germany, respectively. TBE incidence among travelers to these destinations appears to justify TBE vaccination in accordance with World Health Organization recommendations.

Tick-borne encephalitis (TBE) is a substantial public health problem in many parts of Europe and Asia. To assess the effect of increasing TBE vaccination coverage in Austria, we compared incidence rates over 40 years for highly TBE-endemic countries of central Europe (Czech Republic, Slovenia, and Austria). For all 3 countries we found extensive annual and longer range fluctuations and shifts i...

Many infectious diseases are zoonoses, that is, they can be transmitted between vertebrate animals and humans. More than a fifth of zoonotic pathogens are transferred from one host to another by vectors, which are often blood-sucking arthropods, such as ticks. In Europe, Lyme borreliosis, spread by Ixodes ricinus tick, is the most prevalent tick-borne zoonosis. I. ricinus spreads also other zoo...

The ability of passage in HeLa cells to attenuate flaviviruses was investigated for three different strains of the mosquito-borne West Nile (WN) virus and two tick-borne viruses, louping-ill and Langat. One strain of WN virus, Sarawak, was attenuated 4000-fold for adult mice by intraperitoneal or intranasal challenge after six HeLa passages. The HeLa-passaged virus was also found to be antigeni...

tick-borne relapsing fever is an endemic disease in some parts of iran. borellia persica , the most common cause of this disease in iran, has a wide geographic distribution and is present in alborz and zagros mountain chains. here we report a 16–year-old male patient who presented with two episodes of fever within 15 days. he had a history of few overnight stays in a cave of mountainous area in...

Tick-borne spirochetes include borreliae that cause Lyme disease and relapsing fever in humans. They survive in a triangle of parasitic interactions between the spirochete and its vertebrate host, the spirochete and its tick vector, and the host and the tick. Until recently, the significance of vector-host interactions in the transmission of arthropod-borne disease agents has been overlooked. H...

Rhode Island is a state with a high incidence of tick-borne diseases, specifically Lyme disease. The Ioxedes tick which serves as vector for the three most common tick infections is endemic in both the New England and mid-Atlantic regions. However, differences in the density of infections exist within Rhode Island (RI), with the highest densities in the southern counties. Tick-borne diseases ca...

Two enzyme immunoassays for the detection in immunoglobulin M (IgM) antibodies against tick-borne encephalitis virus were compared, employing a solid phase coated either with antigen or with mu-chain-specific antiserum to human IgM. The latter IgM-capturing assay system proved to be more sensitive, and its superiority was especially prominent when high titers of tick-borne encephalitis virus-sp...

The impairment of immune functions in the elderly (immunosenescence) results in post-vaccination antibody titers that are significantly lower than in young individuals. It is, however, a controversial question whether also the quality of antibodies declines with age. In this study, we have therefore investigated the age-dependence of functional characteristics of antibody responses induced by v...